Willson Cyril
EuSci LLC, 1309 S 204th St, #293, Elkhorn, NE 68022, USA.
Toxics. 2023 Mar 10;11(3):258. doi: 10.3390/toxics11030258.
Testosterone is the predominant androgen in men and has important physiological functions. Due to declining testosterone levels from a variety of causes, testosterone replacement therapy (TRT) is increasingly utilized, while testosterone is also abused for aesthetic and performance-enhancing purposes. It has been increasingly speculated that aside from more well-established side effects, testosterone may cause neurological damage. However, the in vitro data utilized to support such claims is limited due to the high concentrations used, lack of consideration of tissue distribution, and species differences in sensitivity to testosterone. In most cases, the concentrations studied in vitro are unlikely to be reached in the human brain. Observational data in humans concerning the potential for deleterious changes in brain structure and function are limited by their inherent design as well as significant potential confounders. More research is needed as the currently available data are limited; however, what is available provides rather weak evidence to suggest that testosterone use or abuse has neurotoxic potential in humans.
睾酮是男性体内主要的雄激素，具有重要的生理功能。由于多种原因导致睾酮水平下降，睾酮替代疗法（TRT）的应用越来越广泛，同时睾酮也被滥用于美容和提高运动表现。越来越多的人推测，除了更为人熟知的副作用外，睾酮可能会导致神经损伤。然而，用于支持此类说法的体外数据有限，原因在于所使用的浓度过高、未考虑组织分布以及不同物种对睾酮敏感性的差异。在大多数情况下，体外研究的浓度不太可能在人脑中达到。关于脑结构和功能有害变化可能性的人体观察数据，受到其固有设计以及显著潜在混杂因素的限制。由于目前可用的数据有限，需要更多的研究；然而，现有的数据提供的证据相当薄弱，表明使用或滥用睾酮在人类中具有神经毒性潜力。
