Department of Chemistry and Biochemistry, University of Colorado at Boulder, Boulder, Colorado 80309, USA.
Nutr Rev. 2012 Aug;70 Suppl 1(Suppl 1):S38-44. doi: 10.1111/j.1753-4887.2012.00493.x.
Rapidly developing sequencing methods and analytical techniques are enhancing our ability to understand the human microbiome, and, indeed, how the microbiome and its constituents are defined. This review highlights recent research that expands our ability to understand the human microbiome on different spatial and temporal scales, including daily time series datasets spanning months. Furthermore, emerging concepts related to defining operational taxonomic units, diversity indices, core versus transient microbiomes, and the possibility of enterotypes are discussed. Additional advances in sequencing technology and in our understanding of the microbiome will provide exciting prospects for exploiting the microbiota for personalized medicine.
快速发展的测序方法和分析技术正在增强我们理解人类微生物组的能力，实际上也在增强我们定义微生物组及其组成部分的能力。这篇综述强调了最近的研究进展，这些进展扩展了我们在不同时空尺度上理解人类微生物组的能力，包括跨越数月的每日时间序列数据集。此外，还讨论了与定义操作分类单元、多样性指数、核心与瞬态微生物组以及存在肠型可能性相关的新兴概念。测序技术的进一步发展和我们对微生物组的理解将为利用微生物组进行个性化医学提供令人兴奋的前景。
