GATA4基因序列变异与酒精依赖的关联。
Association of GATA4 sequence variation with alcohol dependence.
作者信息
Karpyak Victor M, Winham Stacey J, Biernacka Joanna M, Cunningham Julie M, Lewis Kriste A, Geske Jennifer R, Colby Colin L, Abulseoud Osama A, Hall-Flavin Daniel K, Loukianova Larissa L, Schneekloth Terry D, Frye Mark A, Heit John A, Mrazek David A
机构信息
Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA.
出版信息
Addict Biol. 2014 Mar;19(2):312-5. doi: 10.1111/j.1369-1600.2012.00482.x. Epub 2012 Aug 2.
Abstract
To further explore reports of association of alcohol dependence and response to acamprosate treatment with the GATA4 rs13273672 single nucleotide polymorphism (SNP), we genotyped this and 10 other GATA4 SNPs in 816 alcohol-dependent cases and 1248 controls. We tested for association of alcohol dependence with the 11 SNPs individually and performed a global test for association using a principle components analysis. Our analyses demonstrate significant association between GATA4 and alcohol dependence at the gene level (P = 0.009) but no association with rs13273672. Further studies are needed to identify potential causal GATA4 variation(s) and the functional mechanism(s) contributing to this association.
摘要
为了进一步探究酒精依赖与对阿坎酸治疗反应和GATA4基因rs13273672单核苷酸多态性（SNP）之间关联的报道，我们对816例酒精依赖患者和1248名对照者的该SNP以及其他10个GATA4基因SNP进行了基因分型。我们分别检测了这11个SNP与酒精依赖的关联，并使用主成分分析进行了整体关联检验。我们的分析表明，在基因水平上GATA4与酒精依赖之间存在显著关联（P = 0.009），但与rs13273672无关联。需要进一步研究以确定潜在的因果GATA4变异以及促成这种关联的功能机制。
相似文献
1
Association of GATA4 sequence variation with alcohol dependence.GATA4基因序列变异与酒精依赖的关联。
Addict Biol. 2014 Mar;19(2):312-5. doi: 10.1111/j.1369-1600.2012.00482.x. Epub 2012 Aug 2.
2
Involvement of the atrial natriuretic peptide transcription factor GATA4 in alcohol dependence, relapse risk and treatment response to acamprosate.参与性脑钠肽转录因子 GATA4 在酒精依赖、复发风险和乙酰谷酰胺治疗反应中的作用。
Pharmacogenomics J. 2011 Oct;11(5):368-74. doi: 10.1038/tpj.2010.51. Epub 2010 Jun 29.
3
Association Analysis Between Genetic Variation in GATA Binding Protein 4 (GATA4) and Alcohol Use Disorder.GATA结合蛋白4（GATA4）基因变异与酒精使用障碍之间的关联分析
Alcohol Alcohol. 2018 Jul 1;53(4):361-367. doi: 10.1093/alcalc/agx120.
4
GATA4 variant interaction with brain limbic structure and relapse risk: A voxel-based morphometry study.GATA4变异与脑边缘系统结构及复发风险：一项基于体素的形态学研究。
Eur Neuropsychopharmacol. 2016 Sep;26(9):1431-1437. doi: 10.1016/j.euroneuro.2016.06.011. Epub 2016 Jul 7.
5
Genetic variation in the atrial natriuretic peptide transcription factor GATA4 modulates amygdala responsiveness in alcohol dependence.基因变异在心房利钠肽转录因子 GATA4 中调节酒精依赖中的杏仁核反应性。
Biol Psychiatry. 2014 May 15;75(10):790-7. doi: 10.1016/j.biopsych.2013.10.020. Epub 2013 Nov 4.
6
Analysis of Rare Variants in the Alcohol Dependence Candidate Gene GATA4.酒精依赖候选基因GATA4中的罕见变异分析。
Alcohol Clin Exp Res. 2016 Aug;40(8):1627-32. doi: 10.1111/acer.13125. Epub 2016 Jul 4.
7
Genetic variations in the transcription factors and and bleeding complications in patients receiving warfarin therapy.转录因子中的基因变异与接受华法林治疗患者的出血并发症。
Drug Des Devel Ther. 2019 May 17;13:1717-1727. doi: 10.2147/DDDT.S198018. eCollection 2019.
8
Genome-wide association study of alcohol dependence implicates a region on chromosome 11.全基因组关联研究提示染色体 11 上的一个区域与酒精依赖有关。
Alcohol Clin Exp Res. 2010 May;34(5):840-52. doi: 10.1111/j.1530-0277.2010.01156.x. Epub 2010 Mar 1.
9
Association of the PDYN gene with alcohol dependence and the propensity to drink in negative emotional states.PDYN 基因与酒精依赖及负面情绪状态下饮酒倾向的关联。
Int J Neuropsychopharmacol. 2013 Jun;16(5):975-85. doi: 10.1017/S1461145712001137. Epub 2012 Oct 29.
10
Identification and functional study of GATA4 gene regulatory variants in type 2 diabetes mellitus.鉴定和功能研究 GATA4 基因调节变异在 2 型糖尿病。
BMC Endocr Disord. 2021 Apr 17;21(1):73. doi: 10.1186/s12902-021-00739-0.
引用本文的文献
1
Neuronal-specific methylome and hydroxymethylome analysis reveal significant loci associated with alcohol use disorder.神经元特异性甲基化组和羟甲基化组分析揭示了与酒精使用障碍相关的重要基因座。
Front Genet. 2024 Apr 3;15:1345410. doi: 10.3389/fgene.2024.1345410. eCollection 2024.
2
Neuronal-specific methylome and hydroxymethylome analysis reveal replicated and novel loci associated with alcohol use disorder.神经元特异性甲基化组和羟甲基化组分析揭示了与酒精使用障碍相关的重复和新位点。
medRxiv. 2023 Nov 29:2023.11.28.23299094. doi: 10.1101/2023.11.28.23299094.
3
Pharmacogenetics of Addiction Therapy.成瘾治疗的药物遗传学。
Methods Mol Biol. 2022;2547:437-490. doi: 10.1007/978-1-0716-2573-6_16.
4
Atrial natriuretic peptide (ANP): A novel mechanism for reducing ethanol consumption and seeking behaviors in female alcohol preferring (P) rats.心房利钠肽（ANP）：降低雌性酒精偏爱（P）大鼠乙醇摄入量和觅酒行为的新机制。
Peptides. 2020 Dec;134:170403. doi: 10.1016/j.peptides.2020.170403. Epub 2020 Aug 31.
5
Pharmacotherapies and personalized medicine for alcohol use disorder: a review.药物治疗和个体化医学在酒精使用障碍中的应用：综述。
Pharmacogenomics. 2020 Oct;21(15):1117-1138. doi: 10.2217/pgs-2020-0079. Epub 2020 Aug 18.
6
Pharmacogenetics of alcohol use disorder treatments: an update.酒精使用障碍治疗的药物遗传学：更新。
Expert Opin Drug Metab Toxicol. 2019 Jul;15(7):553-564. doi: 10.1080/17425255.2019.1628218. Epub 2019 Jun 11.
7
Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries.通过在多个血统的 57 万多人中进行基因-酒精相互作用，鉴定出了与血压有关的新的遗传关联。
PLoS One. 2018 Jun 18;13(6):e0198166. doi: 10.1371/journal.pone.0198166. eCollection 2018.
8
PNPLA3 Association with Alcoholic Liver Disease in a Cohort of Heavy Drinkers.在一群重度饮酒者中，PNPLA3与酒精性肝病的关联
Alcohol Alcohol. 2018 Jul 1;53(4):357-360. doi: 10.1093/alcalc/agy007.
9
Association Analysis Between Genetic Variation in GATA Binding Protein 4 (GATA4) and Alcohol Use Disorder.GATA结合蛋白4（GATA4）基因变异与酒精使用障碍之间的关联分析
Alcohol Alcohol. 2018 Jul 1;53(4):361-367. doi: 10.1093/alcalc/agx120.
10
Analysis of Rare Variants in the Alcohol Dependence Candidate Gene GATA4.酒精依赖候选基因GATA4中的罕见变异分析。
Alcohol Clin Exp Res. 2016 Aug;40(8):1627-32. doi: 10.1111/acer.13125. Epub 2016 Jul 4.
本文引用的文献
1
Alcohol craving as a predictor of relapse.酒精渴求作为复吸的预测指标。
Am J Addict. 2012 Nov;21 Suppl 1:S20-6. doi: 10.1111/j.1521-0391.2012.00297.x.
2
Genome-wide association study of alcohol dependence implicates KIAA0040 on chromosome 1q.全基因组关联研究提示染色体 1q 上的 KIAA0040 与酒精依赖有关。
Neuropsychopharmacology. 2012 Jan;37(2):557-66. doi: 10.1038/npp.2011.229. Epub 2011 Sep 28.
3
Genetic variation within the anticoagulant, procoagulant, fibrinolytic and innate immunity pathways as risk factors for venous thromboembolism.抗凝、促凝、纤溶和固有免疫途径中的遗传变异作为静脉血栓栓塞的危险因素。
J Thromb Haemost. 2011 Jun;9(6):1133-42. doi: 10.1111/j.1538-7836.2011.04272.x.
4
Ethanol and its metabolites induce histone lysine 9 acetylation and an alteration of the expression of heart development-related genes in cardiac progenitor cells.乙醇及其代谢产物可诱导心肌祖细胞组蛋白赖氨酸 9 乙酰化，并改变心脏发育相关基因的表达。
Cardiovasc Toxicol. 2010 Dec;10(4):268-74. doi: 10.1007/s12012-010-9081-z.
5
Involvement of the atrial natriuretic peptide transcription factor GATA4 in alcohol dependence, relapse risk and treatment response to acamprosate.参与性脑钠肽转录因子 GATA4 在酒精依赖、复发风险和乙酰谷酰胺治疗反应中的作用。
Pharmacogenomics J. 2011 Oct;11(5):368-74. doi: 10.1038/tpj.2010.51. Epub 2010 Jun 29.
6
The transcription factor GATA-4 regulates cytochrome P4502C19 gene expression.转录因子 GATA-4 调节细胞色素 P4502C19 基因的表达。
Life Sci. 2010 May 8;86(19-20):699-706. doi: 10.1016/j.lfs.2010.02.021. Epub 2010 Mar 4.
7
A genome-wide association study of alcohol dependence.一项关于酒精依赖的全基因组关联研究。
Proc Natl Acad Sci U S A. 2010 Mar 16;107(11):5082-7. doi: 10.1073/pnas.0911109107. Epub 2010 Mar 2.
8
Genome-wide association study of alcohol dependence implicates a region on chromosome 11.全基因组关联研究提示染色体 11 上的一个区域与酒精依赖有关。
Alcohol Clin Exp Res. 2010 May;34(5):840-52. doi: 10.1111/j.1530-0277.2010.01156.x. Epub 2010 Mar 1.
9
Interaction of SLC6A4 and DRD2 polymorphisms is associated with a history of delirium tremens.SLC6A4 和 DRD2 多态性的相互作用与震颤谵妄的病史有关。
Addict Biol. 2010 Jan;15(1):23-34. doi: 10.1111/j.1369-1600.2009.00183.x.
10
Genome-wide association study of alcohol dependence.酒精依赖的全基因组关联研究。
Arch Gen Psychiatry. 2009 Jul;66(7):773-84. doi: 10.1001/archgenpsychiatry.2009.83.
Zotero 插件