Histocompatibility and Immunogenetics Laboratory, Cambridge University Teaching Hospitals NHS Foundation Trust, Addenbrooke's Hospital, Cambridge, CB2 0QQ, UK.
Cell Stem Cell. 2012 Aug 3;11(2):147-52. doi: 10.1016/j.stem.2012.07.014.
The likelihood for immunological rejection of Human Leukocyte Antigens (HLA)-mismatched induced pluripotent stem cells (iPSCs) limits their therapeutic potential. Here we show how a tissue bank from 150 selected homozygous HLA-typed volunteers could match 93% of the UK population with a minimal requirement for immunosuppression. Our model provides a practical approach for using existing HLA-typed samples to generate an iPSC stem cell bank that circumvents prospective typing of a large number of individuals.
人类白细胞抗原（HLA）错配诱导多能干细胞（iPSC）的免疫排斥可能性限制了其治疗潜力。在这里，我们展示了如何从 150 名经过精心挑选的纯合 HLA 配型志愿者的组织库中，通过最小程度的免疫抑制来匹配英国 93%的人口。我们的模型提供了一种实用的方法，可利用现有的 HLA 配型样本来生成规避对大量个体进行前瞻性配型的 iPSC 干细胞库。
