New York Stem Cell Foundation, 1995 S. Broadway, New York, NY, 10023, USA.
Stem Cell Rev Rep. 2015 Feb;11(1):1-10. doi: 10.1007/s12015-014-9574-4.
The discovery of induced pluripotent stem cells (iPSCs) and concurrent development of protocols for their cell-type specific differentiation have revolutionized studies of diseases and raised the possibility that personalized medicine may be achievable. Realizing the full potential of iPSC will require addressing the challenges inherent in obtaining appropriate cells for millions of individuals while meeting the regulatory requirements of delivering therapy and keeping costs affordable. Critical to making PSC based cell therapy widely accessible is determining which mode of cell collection, storage and distribution, will work. In this manuscript we suggest that moderate sized bank where a diverse set of lines carrying different combinations of commonly present HLA alleles are banked and differentiated cells are made available to matched recipients as need dictates may be a solution. We discuss the issues related to developing such a bank and how it could be constructed and propose a bank of selected HLA phenotypes from carefully screened healthy individuals as a solution to delivering personalized medicine.
诱导多能干细胞(iPSCs)的发现以及其细胞类型特异性分化方案的同时发展，彻底改变了疾病研究，并提出了实现个性化医疗的可能性。要充分发挥 iPSC 的潜力，就需要解决为数百万人获得合适细胞的固有挑战，同时满足提供治疗和保持成本负担得起的监管要求。实现基于 PSC 的细胞治疗广泛应用的关键是确定哪种细胞采集、存储和分配模式可行。在本文中，我们提出建立一个中等规模的银行，其中存储了一组多样化的细胞系，这些细胞系携带常见 HLA 等位基因的不同组合，并根据需要向匹配的接受者提供分化细胞，这可能是一种解决方案。我们讨论了开发这样一个银行的相关问题，以及如何构建它，并提出了从经过精心筛选的健康个体中选择 HLA 表型的银行，作为提供个性化医疗的解决方案。
