Department of Oral and Maxillofacial Surgery, Hyogo College of Medicine, Hyogo, Japan.
Oral Surg Oral Med Oral Pathol Oral Radiol. 2012 Sep;114(3):318-24. doi: 10.1016/j.oooo.2012.04.002.
This retrospective cohort study was conducted to investigate the influence of wearing dentures in the initial occurrence site of bisphosphonate-related osteonecrosis of the jaws (BRONJ).
A questionnaire regarding the prevalence, therapy, and outcome of jawbone lesions during 2006-08 was mailed to 248 medical institutions with an oral and maxillofacial surgery department in Japan.
Ninety-nine patients wearing dentures had significantly shorter duration until occurrence than 151 patients not wearing dentures. In addition, remission of BRONJ affecting the mandibular canine and premolar region in denture-wearing patients was significantly more difficult. Poor oral hygiene status was found to affect significantly the prognosis of BRONJ in denture-wearing patients. Alcohol habit also delayed remission, but high body mass index promoted remission.
Wearing a denture in the initial occurrence site of BRONJ was shown to influence the prognosis of BRONJ, especially in mandibular denture-wearing patients.
本回顾性队列研究旨在探讨佩戴义齿对口颌骨局部发生双膦酸盐相关性颌骨坏死（BRONJ）的影响。
2006-08 年间，向日本 248 家设有口腔颌面外科的医疗机构邮寄了一份有关颌骨病变的患病率、治疗和结局的调查问卷。
99 名佩戴义齿的患者与 151 名未佩戴义齿的患者相比，BRONJ 发生的时间明显更短。此外，佩戴义齿的患者下颌尖牙和前磨牙区域的 BRONJ 缓解更为困难。口腔卫生状况较差显著影响佩戴义齿患者的 BRONJ 预后。饮酒习惯也会延迟缓解，但高体重指数有助于缓解。
BRONJ 初始发生部位佩戴义齿会影响 BRONJ 的预后，特别是下颌佩戴义齿的患者。
