UCD Institute of Food and Health, University College Dublin, Belfield, Dublin 4, Republic of Ireland.
Proc Nutr Soc. 2012 Nov;71(4):634-8. doi: 10.1017/S0029665112000699. Epub 2012 Aug 6.
The role of metabolomics in the field of nutrition is continuing to grow and it has the potential to assist in the understanding of metabolic regulation and explain how minor perturbations can have a multitude of biochemical endpoints. It is this development, which creates the potential to provide the knowledge necessary to facilitate a more targeted approach to nutrition. In recent years, there has been interest in applying metabolomics to examine alterations in the metabolic profile according to weight gain/obesity. Emerging from these studies is the strong evidence that alterations in the amino acid (AA) profiles are associated with obesity. Several other studies have also shown a relationship between branched-chain amino acids (BCAA), obesity and insulin resistance. The present review focuses on the proposed link between AA and in particular BCAA, obesity and insulin resistance. In conclusion, a wealth of information is accumulating to support the role of AA, and in particular of the BCAA, in obesity.
代谢组学在营养领域的作用不断增强，它有可能帮助我们理解代谢调控，并解释微小的干扰如何能产生众多的生化终点。这种发展有可能为我们提供必要的知识，以促进更有针对性的营养方法。近年来，人们对应用代谢组学来根据体重增加/肥胖来检查代谢谱的变化产生了兴趣。这些研究的结果有力地表明，氨基酸 (AA) 谱的改变与肥胖有关。其他一些研究也表明支链氨基酸 (BCAA)、肥胖和胰岛素抵抗之间存在关系。本综述重点讨论了 AA 特别是 BCAA 与肥胖和胰岛素抵抗之间的可能联系。总之，大量的信息正在积累，以支持 AA，特别是 BCAA，在肥胖中的作用。
