Somersalo Erik, Kautiainen Hannu, Klemetti Miira M, Eriksson Johan G, Laine Merja K
Department of General Practice and Primary Health Care, University of Helsinki, Helsinki University Hospital, Helsinki, Finland.
Folkhälsan Research Center, Helsinki, Finland.
Sci Rep. 2025 Jul 1;15(1):21847. doi: 10.1038/s41598-025-07177-1.
Branched-chain amino acids (BCAAs) are known to be associated with cardiovascular disease risk in adults. The aim of this study is to investigate whether an increased cardiometabolic risk profile can be observed in the amino acid profile of young adult offspring of women with type 1 diabetes. This cross-sectional case-control study included 73 offspring born to women with type 1 diabetes (cases) and 82 control participants (controls). At the age of 18-23 years, they participated in a clinical assessment including laboratory tests and questionnaires. Amino acid levels were analyzed from venous serum samples after 10 h of fasting using nuclear magnetic resonance (NMR) spectroscopy. No differences in cardiovascular disease or cardiometabolic risk factors were observed between the cases and the controls. Circulating amino acid levels were similar in both groups. The glucogenic score (combined alanine, glycine) was higher in overweight case men (case versus controls adjusted p = 0.015 (mean ratio 1.25 [95% CI 1.11 to 1.49]). The present findings do not support our hypothesis that serum amino acid profiles, determined in early adulthood, are associated with a more adverse cardiometabolic risk profile in offspring of women with type 1 diabetes. Further studies are warranted to clarify the potential role of amino acids in the development of cardiovascular disease in offspring of women with type 1 diabetes.
已知支链氨基酸（BCAAs）与成年人的心血管疾病风险相关。本研究的目的是调查在1型糖尿病女性的成年早期后代的氨基酸谱中是否能观察到心脏代谢风险增加的情况。这项横断面病例对照研究纳入了73名1型糖尿病女性所生的后代（病例组）和82名对照参与者（对照组）。在18至23岁时，他们参与了包括实验室检查和问卷调查在内的临床评估。使用核磁共振（NMR）光谱法对禁食10小时后的静脉血清样本中的氨基酸水平进行了分析。病例组和对照组之间未观察到心血管疾病或心脏代谢风险因素的差异。两组的循环氨基酸水平相似。超重病例组男性的生糖评分（丙氨酸、甘氨酸合并）较高（病例组与对照组相比，校正后p = 0.015（平均比值1.25 [95%置信区间1.11至1.49]）。本研究结果不支持我们的假设，即在成年早期测定的血清氨基酸谱与1型糖尿病女性后代更不利的心脏代谢风险谱相关。有必要进行进一步研究以阐明氨基酸在1型糖尿病女性后代心血管疾病发生发展中的潜在作用。
