Key Laboratory of Molecular Epidemiology of Hunan Province, School of Medicine, Hunan Normal University, Changsha 410013, China.
Department of Physiology, Faculty of Medicine, University of Alexandria, Alexandria 21526, Egypt.
Nutrients. 2022 Jun 15;14(12):2471. doi: 10.3390/nu14122471.
Amino acids (AAs) and dietary inflammatory potential play essential roles in muscle health. We examined the associations of dietary inflammatory index (DII) of habitual diet with serum AA profile, and ascertained if the associations between DII and muscle outcomes were mediated by serum AAs, in 2994 older Chinese community-dwelling men and women (mean age 72 years) in Hong Kong. Higher serum branched chain AAs (BCAAs), aromatic AAs and total glutathione (tGSH) were generally associated with better muscle status at baseline. A more pro-inflammatory diet, correlating with higher serum total homocysteine and cystathionine, was directly (90.2%) and indirectly (9.8%) through lower tGSH associated with 4-year decline in hand grip strength in men. Higher tGSH was associated with favorable 4-year changes in hand grip strength, gait speed and time needed for 5-time chair stands in men and 4-year change in muscle mass in women. Higher leucine and isoleucine were associated with decreased risk of sarcopenia in men; the associations were abolished after adjustment for BMI. In older men, perturbations in serum sulfur AAs metabolism may be biomarkers of DII related adverse muscle status, while the lower risk of sarcopenia with higher BCAAs may partly be due to preserved BMI.
氨基酸 (AAs) 和饮食炎症潜能在肌肉健康中起着重要作用。我们研究了习惯性饮食的饮食炎症指数 (DII) 与血清 AA 谱之间的关系，并确定 DII 与肌肉结果之间的关联是否通过血清 AA 介导，在香港的 2994 名年龄在 72 岁及以上的中国社区居住的男性和女性中进行。较高的血清支链氨基酸 (BCAAs)、芳香族氨基酸和总谷胱甘肽 (tGSH) 通常与基线时更好的肌肉状态相关。更促炎的饮食与更高的血清总同型半胱氨酸和胱硫醚有关，与男性握力 4 年下降直接相关（90.2%）和间接相关（9.8%），通过降低 tGSH 相关。较高的 tGSH 与男性握力、步态速度和 5 次坐姿站立所需时间的 4 年变化以及女性肌肉质量的 4 年变化相关。较高的亮氨酸和异亮氨酸与男性肌少症风险降低相关；在调整 BMI 后，这些关联被消除。在老年男性中，血清硫氨基酸代谢的改变可能是 DII 相关不良肌肉状态的生物标志物，而较高的 BCAAs 与肌少症风险降低可能部分归因于 BMI 的保留。
