Department of Ophthalmology, University Medical Center Utrecht, The Netherlands.
Acta Ophthalmol. 2013 Sep;91(6):492-7. doi: 10.1111/j.1755-3768.2012.02483.x. Epub 2012 Aug 3.
To investigate the prognosis and complications in patients with peripheral multifocal chorioretinitis (PMC). PMC is a posterior or panuveitis characterized by chronic bilateral vitritis and punched-out lesions in the peripheral retina which occurs commonly in elderly white women and is associated with sarcoidosis. Prognosis and complications are largely unknown.
A structured literature search in PubMed, Embase and Cochrane was performed to identify relevant articles. Articles were screened, and the remaining articles were critically appraised based on relevance and validity.
The search yielded 267 articles. Eight relevant articles were retrieved. All studies reported on moderate visual impairment. Macular oedema occurred in 60% of the patients with PMC (range, 0-71%), glaucoma in 27% (range, 25-43%) and an epiretinal membrane in 21% (range, 0-28%). In total, 47% had proven or presumed sarcoidosis. Treatment usually comprised topical corticosteroids, periocular steroid injections and systemic corticosteroids regularly in combination with methotrexate.
The prognosis of patients with PMC is characterized by a rather poor visual outcome and the relatively high prevalence of complications. PMC is strongly associated with sarcoidosis. Solid proof for the treatment efficacy of PMC is lacking.
探讨多发性周边性脉络膜炎（PMC）患者的预后和并发症。PMC 是一种后葡萄膜炎或全葡萄膜炎，其特征为慢性双侧虹膜炎和周边视网膜出现凿孔样病变，常见于老年白人女性，与结节病有关。目前对其预后和并发症知之甚少。
对 PubMed、Embase 和 Cochrane 进行了系统的文献检索，以确定相关文章。对文章进行筛选，并根据相关性和有效性对剩余的文章进行批判性评估。
搜索结果共 267 篇文章。检索到 8 篇相关文章。所有研究均报告中度视力障碍。PMC 患者中有 60%（范围 0-71%）出现黄斑水肿，27%（范围 25-43%）出现青光眼，21%（范围 0-28%）出现视网膜前膜。共有 47%的患者被证实或疑似患有结节病。治疗通常包括局部皮质类固醇、眼周皮质类固醇注射和全身皮质类固醇，经常与甲氨蝶呤联合使用。
PMC 患者的预后特征是视力结果相当差，并发症的发病率相对较高。PMC 与结节病密切相关。缺乏对 PMC 治疗效果的确凿证据。
