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近视与炎症的相互作用:综述

Crosstalk between Myopia and Inflammation: A Mini Review.

机构信息

Shandong University of Traditional Chinese Medicine, Jinan 250002, China.

Affiliated Eye Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250002, China.

出版信息

Int J Med Sci. 2024 Jun 3;21(9):1589-1603. doi: 10.7150/ijms.94826. eCollection 2024.

Abstract

Myopia represents a significant public health concern worldwide, particularly affecting the ocular health of children and adolescents. The escalating prevalence of myopia in recent years underscores its urgency as a health issue among this demographic. Research indicates a profound connection between the onset of myopia, inflammatory processes and fibrosis. Individuals with inflammatory conditions like allergic conjunctivitis, choroiditis, systemic lupus erythematosus, and diabetes exhibit a heightened susceptibility to myopia. Conversely, myopic patients are at an increased risk of developing ocular inflammatory disorders, notably idiopathic multifocal choroiditis. We postulate that the expression of inflammatory markers, including NF-κB, TGF-β, IL-1β, IL-6, IL-8, and TNF-α, may contribute to the chronic inflammatory state observed in myopia. This paper highlights a substantial correlation between myopia and inflammation, suggesting the potential efficacy of anti-inflammatory agents in managing inflammation and slowing myopia progression.

摘要

近视是一个全球性的重大公共卫生问题,尤其影响儿童和青少年的眼部健康。近年来,近视的患病率不断上升,凸显了这一问题在该人群中的紧迫性。研究表明,近视的发生与炎症过程和纤维化之间存在着深刻的联系。患有过敏性结膜炎、脉络膜炎、系统性红斑狼疮和糖尿病等炎症性疾病的个体,对近视的易感性明显增加。相反,近视患者发生眼部炎症性疾病的风险增加,特别是特发性多灶性脉络膜炎。我们推测,炎症标志物的表达,包括 NF-κB、TGF-β、IL-1β、IL-6、IL-8 和 TNF-α,可能导致近视中观察到的慢性炎症状态。本文强调了近视和炎症之间的显著相关性,表明抗炎药物在控制炎症和减缓近视进展方面可能具有潜在的疗效。

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