Children's Hospital Colorado, Aurora, CO 80045, USA.
J Pediatr. 2013 Jan;162(1):16-21. doi: 10.1016/j.jpeds.2012.06.043. Epub 2012 Aug 3.
To assess whether children with influenza who are exposed to secondhand tobacco smoke (SHS) would have more severe illness than those not exposed.
We abstracted charts from pediatric inpatients with confirmed influenza from 2002-2009 for demographics, medical history, and smoke exposure. Severity indicators included intensive care, intubation, and length of stay (LOS) in the hospital; potential confounding factors included demographics and the presence of asthma or chronic conditions. All χ(2), t tests, and regression analyses were run using SPSS v. 18.0.
Of 117 children, 40% were exposed to SHS, who had increased need for intensive care (30% vs 10%, P < .01) and intubation (13% vs 1%, P < .05), and had longer LOS (4.0 vs 2.4 days, P < .01). Children with chronic conditions and SHS exposure required more intensive care (53% vs 18%, P < .05) and had longer LOS (10.0 vs 3.5 days, P < .01) than children not exposed to SHS with chronic conditions. In multivariate analyses controlling for potential confounding factors, children with SHS exposure were 4.7 times more likely to be admitted to intensive care (95% CI 1.4-18.5) and had a 70% longer LOS (95% CI 12%-230%).
Children with SHS exposure who are hospitalized with influenza have more severe illness. Efforts are needed to immunize this population against influenza, and eliminate children's exposure to SHS.
评估暴露于二手烟（SHS）的流感患儿的病情是否比未暴露于 SHS 的患儿更严重。
我们从 2002 年至 2009 年的儿科住院患者中提取了确诊为流感的患儿的图表，以获取人口统计学、病史和吸烟暴露情况。严重程度指标包括重症监护、插管和住院时间（LOS）；潜在的混杂因素包括人口统计学和哮喘或慢性疾病的存在。所有 χ(2)、t 检验和回归分析均使用 SPSS v. 18.0 进行。
在 117 名儿童中，有 40%暴露于 SHS，他们需要更多的重症监护（30%比 10%，P<.01）和插管（13%比 1%，P<.05），并且住院时间更长（4.0 天比 2.4 天，P<.01）。有慢性疾病和 SHS 暴露的儿童需要更多的重症监护（53%比 18%，P<.05），住院时间更长（10.0 天比 3.5 天，P<.01）比没有 SHS 暴露且患有慢性疾病的儿童。在控制潜在混杂因素的多变量分析中，暴露于 SHS 的儿童更有可能被收入重症监护病房（95%CI 1.4-18.5），并且 LOS 延长了 70%（95%CI 12%-230%）。
因流感住院的暴露于 SHS 的儿童病情更严重。需要努力为这一人群接种流感疫苗，并消除儿童暴露于 SHS。
