Department of Internal Medicine, Endocrinology & Metabolism and Biochemistry, Section of Endocrinology and Metabolism, University of Siena, Via Bracci, 53100 Siena, Italy.
Best Pract Res Clin Endocrinol Metab. 2012 Aug;26(4):421-9. doi: 10.1016/j.beem.2012.07.001. Epub 2012 Jul 15.
Nowadays the most commonly occurring differentiated thyroid cancer in many countries is a microcarcinoma in patients older than 45 years, incidentally found during neck ultrasound. In view of their low morbidity and mortality, the crucial point is how to manage such microcarcinomas. Recently published European and American guidelines aim to minimize the diagnostic and therapeutic procedures without affecting the diagnostic accuracy and the therapeutic effectiveness, keeping in mind that we are dealing with patients who have a normal life expectancy and to whom we have to guarantee an excellent quality of life. The present review will summarize the clinical and pathological features of thyroid microcarcinoma, including its definition, prevalence, presentation, pathology, genetic, clinical impact and will try to derive from them a rationale for therapeutic and diagnostic intervention.
如今，在许多国家，年龄大于 45 岁的患者中最常见的分化型甲状腺癌是偶然在颈部超声检查中发现的微癌。鉴于其发病率和死亡率较低，关键是如何处理此类微癌。最近发表的欧洲和美国指南旨在在不影响诊断准确性和治疗效果的情况下，尽量减少诊断和治疗程序，同时牢记我们正在处理的是具有正常预期寿命的患者，并且我们必须保证他们的生活质量。本综述将总结甲状腺微癌的临床和病理特征，包括其定义、流行率、表现、病理学、遗传学、临床影响，并试图从中得出治疗和诊断干预的合理依据。
