Cantin André M, Bilodeau Ginette, Larivée Pierre, Richter Martin V
Respiratory Division, Department of Medicine, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Quebec.
Clin Invest Med. 2012 Jul 4;35(4):E173-81. doi: 10.25011/cim.v35i4.17145.
The purpose of this study was to determine whether plasma biomarkers reflect changes in lung function and respiratory exacerbations associated with CF lung disease.
Plasma human leukocyte elastase/alpha1 antitrypsin complex (pHLE complex) values were measured in 28 adult CF patients and 47 healthy volunteers and correlated with forced expiratory volume (FEV1) and forced vital capacity (FVC). pHLE complexes were studied during respiratory exacerbations and after antibiotic therapy. Plasma cytokines and sialic acid were also measured.
pHLE complexes were increased in CF patients (p < 0.01), were inversely correlated with FEV1 (r = 0.71) and FVC (r = 0.67) and returned to normal levels after intravenous antibiotics (p < 0.001). Plasma cytokines did not correlate with lung function. Total sialic acid increased during CF respiratory exacerbations and decreased after antibiotic therapy.
Plasma sialic acid and pHLE complexes reflect clinically meaningful changes in CF lung disease. In contrast, plasma cytokine levels did not correlate with lung function.
本研究的目的是确定血浆生物标志物是否反映与囊性纤维化肺病相关的肺功能变化和呼吸道加重情况。
对28名成年囊性纤维化患者和47名健康志愿者测量血浆人白细胞弹性蛋白酶/α1抗胰蛋白酶复合物（pHLE复合物）值，并将其与用力呼气量（FEV1）和用力肺活量（FVC）相关联。在呼吸道加重期间和抗生素治疗后研究pHLE复合物。还测量了血浆细胞因子和唾液酸。
囊性纤维化患者的pHLE复合物增加（p < 0.01），与FEV1（r = 0.71）和FVC（r = 0.67）呈负相关，静脉注射抗生素后恢复到正常水平（p < 0.001）。血浆细胞因子与肺功能无关。在囊性纤维化呼吸道加重期间总唾液酸增加，抗生素治疗后减少。
血浆唾液酸和pHLE复合物反映了囊性纤维化肺病临床上有意义的变化。相比之下，血浆细胞因子水平与肺功能无关。
