SCF Pharma, 235, route du Fleuve Ouest, Ste-Luce, QC G0K 1P0, Canada.
Department of Medicine, Respiratory Division, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada.
Mar Drugs. 2018 May 26;16(6):184. doi: 10.3390/md16060184.
Omega-3 polyunsaturated fatty acid (n-3 PUFA) supplementations are thought to improve essential fatty acid deficiency (EFAD) as well as reduce inflammation in Cystic Fibrosis (CF), but their effectiveness in clinical studies remains unknown. The aim of the study was to determine how the medical food containing docosahexaenoic acid monoglyceride (MAG-DHA) influenced erythrocyte fatty acid profiles and the expression levels of inflammatory circulating mediators. We conducted a randomized, double blind, pilot trial including fifteen outpatients with Cystic Fibrosis, ages 18⁻48. The patients were divided into 2 groups and received MAG-DHA or a placebo (sunflower oil) for 60 days. Patients took 8 × 625 mg MAG-DHA softgels or 8 × 625 mg placebo softgels every day at bedtime for 60 days. Lipid analyses revealed that MAG-DHA increased docosahexaenoic acid (DHA) levels and decrease arachidonic acid (AA) ratio (AA/DHA) in erythrocytes of CF patients following 1 month of daily supplementation. Data also revealed a reduction in plasma human leukocyte elastase (pHLE) complexes and interleukin-6 (IL-6) expression levels in blood samples of MAG-DHA supplemented CF patients. This pilot study indicates that MAG-DHA supplementation corrects erythrocyte AA/DHA imbalance and may exert anti-inflammatory properties through the reduction of pHLE complexes and IL6 in blood samples of CF patients.
Pro-resolving Effect of MAG-DHA in Cystic Fibrosis (PREMDIC), NCT02518672.
ω-3 多不饱和脂肪酸（n-3PUFA）补充剂被认为可改善必需脂肪酸缺乏症（EFAD）并减轻囊性纤维化（CF）的炎症，但它们在临床研究中的有效性尚不清楚。本研究的目的是确定含有二十二碳六烯酸单甘油酯（MAG-DHA）的医学食品如何影响红细胞脂肪酸谱和炎症循环介质的表达水平。我们进行了一项随机、双盲、初步试验，纳入了 15 名年龄在 18⁻48 岁的 CF 门诊患者。患者分为两组，分别接受 MAG-DHA 或安慰剂（葵花籽油）治疗 60 天。患者每天睡前服用 8×625mg MAG-DHA 软胶囊或 8×625mg 安慰剂软胶囊，持续 60 天。脂质分析显示，MAG-DHA 可增加 CF 患者红细胞中的二十二碳六烯酸（DHA）水平并降低花生四烯酸（AA）比值（AA/DHA），这一结果在每日补充 1 个月后显现。数据还显示，MAG-DHA 补充剂可降低 CF 患者血液中白细胞弹性蛋白酶（pHLE）复合物和白细胞介素-6（IL-6）的表达水平。这项初步研究表明，MAG-DHA 补充剂可纠正红细胞 AA/DHA 失衡，并通过降低 CF 患者血液中的 pHLE 复合物和 IL6 发挥抗炎作用。
MAG-DHA 在囊性纤维化中的促分解效应（PREMDIC），NCT02518672。
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