抗抑郁治疗前后重性抑郁障碍患者 5-HT(1A) 受体结合的变化：一项先导性 [¹⁸F]MPPF 正电子发射断层扫描研究。
5-HT(1A) receptor binding changes in patients with major depressive disorder before and after antidepressant treatment: a pilot [¹⁸F]MPPF positron emission tomography study.
机构信息
Université de Lyon, Lyon, France.
出版信息
Psychiatry Res. 2012 Jul 30;203(1):103-4. doi: 10.1016/j.pscychresns.2011.09.001. Epub 2012 Aug 3.
Abstract
This is the first [¹⁸F]MPPF PET study in positron emission tomography study in depressed patients, both before and after treatment with a selective serotonin reuptake inhibitor (SSRI). Dynamic changes in [¹⁸F]MPPF binding potential were observed primarily in the medial orbital regions from baseline to 30 days of treatment, suggesting SSRI-mediated serotoninergic adaptative mechanisms.
摘要
这是首次在抑郁症患者中进行的 [¹⁸F]MPPF PET 研究，包括治疗前和使用选择性 5-羟色胺再摄取抑制剂（SSRI）治疗后。从基线到治疗 30 天期间，主要观察到 [¹⁸F]MPPF 结合潜能的动态变化发生在眶内侧区域，表明 SSRI 介导的 5-羟色胺能适应性机制。
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