从柬埔寨采集的钝叶龙脑香茎中提取的细胞毒性萜类化合物。

Cytotoxic terpenes from the stems of Dipterocarpus obtusifolius collected in Cambodia.

作者信息

Khiev Piseth, Kwon Ok-Kyoung, Song Hyuk-Hwan, Oh Sei-Ryang, Ahn Kyung-Seop, Lee Hyeong-Kyu, Chin Young-Won

机构信息

University of Science & Technology, Daejeon 305-806, Korea.

出版信息

Chem Pharm Bull (Tokyo). 2012;60(8):955-61. doi: 10.1248/cpb.c12-00012.

DOI:10.1248/cpb.c12-00012

PMID:22863697

Abstract

From the stems of Dipterocarpus obtusifolius, five new triterpenes, 3-oxo-20-hydroxy-30α-methyl,17(29)α-epoxy-28-norlupane (1), 3-oxo-20-hydroxy-30β-methyl-17(29)α-epoxy-28-norlupane (2), 3,20-dioxo-28,29-norlupan-17α-ol (3), 27-demethyl-20(S)-dammar-23-ene-20-ol-3,25-dione (4), and 3-epi-cecropic acid (5) together with 13 known compounds including diterpene, sesquiterpenes and triterpenes were isolated and characterized. All isolates were tested for their cytotoxicities against a small panel of human cancer cell lines. Of the tested compounds, compounds 4-11 were found to be cytotoxic against one or more human cancer cell lines.

摘要

从钝叶龙脑香的茎中，分离并鉴定出5个新的三萜类化合物，即3-氧代-20-羟基-30α-甲基-17(29)α-环氧-28-降羽扇豆烷(1)、3-氧代-20-羟基-30β-甲基-17(29)α-环氧-28-降羽扇豆烷(2)、3,20-二氧代-28,29-降羽扇豆烷-17α-醇(3)、27-去甲基-20(S)-达玛-23-烯-20-醇-3,25-二酮(4)和3-表-西克罗皮酸(5)，以及13个已知化合物，包括二萜类、倍半萜类和三萜类。对所有分离物进行了针对一小部分人类癌细胞系的细胞毒性测试。在测试的化合物中，化合物4-11对一种或多种人类癌细胞系具有细胞毒性。