从海洋红树林植物白骨壤中分离得到的三种新的海松烷二萜类化合物。

Three new pimaren diterpenoids from marine mangrove plant, Bruguiera gymnorrhiza.

作者信息

Han Li, Huang Xueshi, Sattler I, Dahse H M, Fu Hongzheng, Grabley S, Lin Wenhan

机构信息

State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, PR China.

出版信息

Pharmazie. 2005 Sep;60(9):705-7.

PMID:16222873

Abstract

Three new pimaren diterpenoids, ent-8(14)-pimarene-15R, 16-diol (1), ent-8(14)-pimarene-1alpha,15R,16-triol (2), and (5R, 9S, 10R, 13S, 15S)-ent-8(14)-pimarene-1-oxo-15R,16-diol (3), along with three known diterpenoids (4-6) have been isolated from the stem of mangrove plant Bruguiera gymnorrhiza. The structures of compounds 1-3 were determined by extensive spectroscopic (2D NMR, MS, IR, and CD) analysis, and 3 and 5 showed moderate cytotoxic activities against L-929 and K562, respectively.

摘要

从红树植物白骨壤的茎中分离出了三种新的海松烷二萜类化合物，对映-8(14)-海松烯-15R,16-二醇（1）、对映-8(14)-海松烯-1α,15R,16-三醇（2）和(5R, 9S, 10R, 13S, 15S)-对映-8(14)-海松烯-1-氧代-15R,16-二醇（3），以及三种已知的二萜类化合物（4-6）。通过广泛的光谱（二维核磁共振、质谱、红外光谱和圆二色光谱）分析确定了化合物1-3的结构，化合物3和5分别对L-929和K562显示出中等的细胞毒性活性。