Cao Xiaoying, Geng Jianning, Su Suwen, Zhang Linan, Xu Qian, Zhang Li, Xie Yinghua, Wu Shaomei, Sun Yongjun, Gao Zibin
Department of Pharmacy, Hebei University of Science and Technology, Yuhua East Road 70, Shijiazhuang 050018, PR China.
Chem Pharm Bull (Tokyo). 2012;60(10):1227-33. doi: 10.1248/cpb.c12-00270. Epub 2012 Aug 1.
A novel drug delivery system of doxorubicin (DOX)-loaded Zein in situ gel for interstitial chemotherapy was investigated in this study. The possible mechanisms of drug release were described according to morphological analysis by optical microscopy and scanning electronic microscope (SEM). In vitro and in vivo anti-tumor activity studies showed that DOX-loaded Zein in situ gel was superior to DOX solution. Local pharmacokinetics in tumor tissue was studied by quantitative analysis with confocal laser scanning microscopy (CLSM) combined with microdialysis technology. A pharmacokinetics mathematical model of DOX-loaded Zein in situ gel in tumors was then built.
本研究考察了一种用于间质化疗的载有多柔比星（DOX）的玉米醇溶蛋白原位凝胶新型给药系统。根据光学显微镜和扫描电子显微镜（SEM）的形态学分析描述了药物释放的可能机制。体外和体内抗肿瘤活性研究表明，载DOX的玉米醇溶蛋白原位凝胶优于DOX溶液。采用共聚焦激光扫描显微镜（CLSM）结合微透析技术进行定量分析，研究了肿瘤组织中的局部药代动力学。然后建立了载DOX的玉米醇溶蛋白原位凝胶在肿瘤中的药代动力学数学模型。
