Petersen Andrew J, Wassarman David A
Molecular and Cellular Pharmacology Program, University of Wisconsin School of Medicine and Public Health, Madison, WI USA.
Fly (Austin). 2012 Jul-Sep;6(3):169-72. doi: 10.4161/fly.20999. Epub 2012 Jul 1.
In this Extra View, we highlight recent Drosophila research that has uncovered a new role for the innate immune response. The research indicates that, in addition to combating infection, the innate immune response promotes neurodegeneration. Our publication (Petersen et al., 2012) reveals a correlative relationship between the innate immune response and neurodegeneration in a model of the human disease Ataxia-telangiectasia (A-T). We also found that glial cells are responsible for the innate immune response in the A-T model, and work by others implicates glial cells in neurodegeneration. Additionally, publications by Chinchore et al. (2012) and Tan et al. (2008) reveal a causative role for the innate immune response in models of human retinal degenerative disorders and Alzheimer disease, respectively. Collectively, these findings suggest that activation of the innate immune response is a shared cause of neurodegeneration in different human diseases.
在这篇“额外视角”文章中，我们重点介绍了近期果蝇研究，该研究揭示了先天免疫反应的新作用。研究表明，先天免疫反应除了对抗感染外，还会促进神经退行性变。我们的出版物（彼得森等人，2012年）揭示了人类疾病共济失调毛细血管扩张症（A-T）模型中先天免疫反应与神经退行性变之间的相关性。我们还发现，胶质细胞在A-T模型中负责先天免疫反应，而其他人的研究表明胶质细胞与神经退行性变有关。此外，钦乔尔等人（2012年）和谭等人（2008年）的出版物分别揭示了先天免疫反应在人类视网膜退行性疾病模型和阿尔茨海默病模型中的致病作用。总体而言，这些发现表明先天免疫反应的激活是不同人类疾病中神经退行性变的共同原因。
