Li Taotao, Yang Jianfeng, Zhou Quansheng, He Yulong
Laboratory of Vascular and Cancer Biology, Cyrus Tang Hematology Center, Thrombosis and Hemostasis Key Lab of the Ministry of Health, Jiangsu Institute of Hematology, the First Affiliated Hospital, Soochow University, Suzhou, China.
Cancer Microenviron. 2012 Dec;5(3):249-60. doi: 10.1007/s12307-012-0119-6. Epub 2012 Aug 4.
A rapid progress has been made in the field of lymphatic research during the last 15 years. This includes better understanding of the cellular events and molecular players involved in the lymphatic vessel formation and remodeling in development. The key players identified in developmental lymphangiogenesis, including vascular endothelial cell growth factor-C (VEGF-C) / VEGFR-3 and angiopoietins (ANGPTs)/ TIE pathways, are also crucial for pathological lymphatic vessel growth. In solid tumor, tumor cells as well as tumor-associated stromal cells, such as tumor-infiltrating leukocytes, contribute to intra- and peri-tumoral lymphangiogenesis via secreting lymphangiogenic growth factors. Tumor-associated lymphatic endothelial cells also interact actively with tumor cells and leukocytes via secreting various chemokines. It has been well established that tumor lymphangiogenesis promotes tumor cell dissemination to regional lymph nodes. Thus manipulation of lymphangiogenic microenvironment could become another valuable approach in the combat of tumor progression.
在过去15年里，淋巴研究领域取得了快速进展。这包括对发育过程中淋巴管形成和重塑所涉及的细胞事件和分子参与者有了更好的理解。在发育性淋巴管生成中确定的关键参与者，包括血管内皮生长因子-C（VEGF-C）/VEGFR-3和血管生成素（ANGPTs）/TIE途径，对病理性淋巴管生长也至关重要。在实体瘤中，肿瘤细胞以及肿瘤相关基质细胞，如肿瘤浸润白细胞，通过分泌淋巴管生成生长因子促进肿瘤内和肿瘤周围的淋巴管生成。肿瘤相关淋巴管内皮细胞还通过分泌各种趋化因子与肿瘤细胞和白细胞积极相互作用。肿瘤淋巴管生成促进肿瘤细胞扩散至区域淋巴结，这一点已经得到充分证实。因此，操纵淋巴管生成微环境可能成为对抗肿瘤进展的另一种有价值的方法。
