Tytgat Institute for Liver and Intestinal Research, the Academic Medical Center, Amsterdam, The Netherlands.
Eur J Immunol. 2012 Aug;42(8):1916-23. doi: 10.1002/eji.201242639.
Cells that belong to the family of innate lymphoid cells (ILCs) not only form a first line of defense against invading microbes, but also play essential roles in tissue remodeling and immune pathology. Rorγt(+) ILCs, producing the cytokines IL-22 and IL-17, include lymphoid tissue inducer (LTi) cells which are critical for the formation of lymphoid structures. Recently another ILC subset has been identified, which is dependent on RORα for its development and is dedicated to the production of the Th2 cytokines IL-5 and IL-13. These ILCs have been termed type 2 ILCs. All ILC subets are considered to belong to the same family that also includes natural killer cells because they all rely on the common γ-chain (γc) of the IL-2 receptor for their development and function, share a lymphoid morphology and depend on the transcriptional repressor Id2 for their development. Other transcription factors, including Notch, and the aryl hydrocarbon receptor (AhR) in RORγt(+) ILCs and GATA3 in type 2 ILCs, also play roles in the development, survival, and function of these ILC subpopulations. Here we review the current knowledge with regard to the transcription factors involved in the development and functions of ILCs.
属于固有淋巴细胞 (ILC) 家族的细胞不仅构成了抵御入侵微生物的第一道防线，而且在组织重塑和免疫病理中也发挥着重要作用。产生细胞因子 IL-22 和 IL-17 的 Rorγt(+) ILC 包括淋巴组织诱导 (LTi) 细胞，它们对于淋巴结构的形成至关重要。最近，又鉴定出另一种 ILC 亚群，其发育依赖于 RORα，并专门产生 Th2 细胞因子 IL-5 和 IL-13。这些 ILC 被称为 2 型 ILC。所有 ILC 亚群都被认为属于同一个家族，因为它们都依赖于 IL-2 受体的共同 γ 链 (γc) 来发育和发挥功能，具有淋巴样形态，并依赖转录抑制因子 Id2 来发育。其他转录因子，包括 Notch 和 Rorγt(+) ILC 中的芳香烃受体 (AhR) 以及 2 型 ILC 中的 GATA3，也在这些 ILC 亚群的发育、存活和功能中发挥作用。在这里，我们综述了涉及 ILC 发育和功能的转录因子的最新知识。
