Sindhu Edakkadath R, Kuttan Ramadasan
Amala Cancer Research Center, Kerala, India.
J Basic Clin Physiol Pharmacol. 2012 Jan 19;23(1):33-7. doi: 10.1515/jbcpp-2011-0032.
Carotenoid lutein was evaluated for antiulcerogenic activity in rats.
Gastric ulcer was induced in fasted rats by oral administration of ethanol (95%) (5 mL/kg body weight). Lutein (100 and 250 mg/kg body weight) was administered everyday for 5 days prior to alcohol administration.
The ulcer index which is a measure of the severity of ulcers was found to be reduced in lutein-treated groups. Morphological and histopathological examination supported the protection of lutein during alcohol-induced damage in rat stomach. Antioxidant enzymes, such as catalase, super oxide dismutase, glutathione peroxidase as well as glutathione levels, which were found to be reduced in the gastric mucosa of alcohol-treated groups, were found to be elevated after lutein treatment.
The mechanism of antiulcer activity may be due to the inhibition of oxidative stress produced by alcohol by lutein administration. These findings suggest the potential therapeutic use of lutein as an effective antiulcer agent.
评估了类胡萝卜素叶黄素对大鼠的抗溃疡活性。
通过口服给予禁食大鼠乙醇（95%）（5毫升/千克体重）诱导胃溃疡。在给予酒精前5天，每天给予叶黄素（100和250毫克/千克体重）。
发现叶黄素治疗组的溃疡指数（衡量溃疡严重程度的指标）降低。形态学和组织病理学检查支持叶黄素对大鼠胃酒精诱导损伤的保护作用。在酒精治疗组胃黏膜中发现降低的抗氧化酶，如过氧化氢酶、超氧化物歧化酶、谷胱甘肽过氧化物酶以及谷胱甘肽水平，在叶黄素治疗后升高。
抗溃疡活性机制可能是由于叶黄素给药抑制了酒精产生的氧化应激。这些发现表明叶黄素作为一种有效的抗溃疡剂具有潜在的治疗用途。
