Graninger W, Presterl E, Walzl B, Lackner R, Haslinger B, Hackl W
Department of Chemotherapy, University of Vienna, Austria.
J Antimicrob Chemother. 1990 Nov;26 Suppl D:123-35. doi: 10.1093/jac/26.suppl_d.123.
The efficacy and tolerance of intravenous ofloxacin was studied in 70 patients suffering from soft tissue infections (n = 33), intra-abdominal abscesses (n = 14), septicaemia (n = 12), pneumonia (n = 9) and brucellosis (n = 2). The average daily dose was 6 mg/kg divided into two doses. Pathogens treated included Enterobacter cloacae (n = 14), Escherichia coli (n = 12), Staphylococcus aureus (n = 13), Pseudomonas aeruginosa (n = 11), Klebsiella pneumoniae (n = 10), Enterococcus faecalis (n = 8) and Streptococcus spp. (n = 5). Most patients had several underlying diseases. Most of the patients had received other antibiotic therapy without success. Clinically, 41% were considered cured, 19% improved and 30% failed to respond. Bacteriologically, pathogens were eradicated in 52.5% and persisted in 22.5%. Adverse reactions included an anaphylactoid reaction, abnormal liver function (n = 13) and insomnia (n = 2). This study suggests that higher doses of ofloxacin may be needed in deep seated infections.
对70例患有软组织感染（n = 33）、腹腔脓肿（n = 14）、败血症（n = 12）、肺炎（n = 9）和布鲁氏菌病（n = 2）的患者研究了静脉注射氧氟沙星的疗效和耐受性。平均日剂量为6mg/kg，分两次给药。治疗的病原体包括阴沟肠杆菌（n = 14）、大肠杆菌（n = 12）、金黄色葡萄球菌（n = 13）、铜绿假单胞菌（n = 11）、肺炎克雷伯菌（n = 10）、粪肠球菌（n = 8）和链球菌属（n = 5）。大多数患者有几种基础疾病。大多数患者接受过其他抗生素治疗但无效。临床上，41%被认为治愈，19%病情改善，30%无反应。细菌学上，病原体根除率为52.5%，持续存在率为22.5%。不良反应包括类过敏反应、肝功能异常（n = 13）和失眠（n = 2）。这项研究表明，深部感染可能需要更高剂量的氧氟沙星。
