Giamarellou H, Tsagarakis J
Athens University School of Medicine, First Department Propedeutic Medicine.
Drugs. 1987;34 Suppl 1:119-23. doi: 10.2165/00003495-198700341-00026.
66 patients were given daily doses of ofloxacin between 400 and 800 mg for 10 days to 6 months. They were suffering from exacerbation of chronic bronchitis (15), soft tissue phlegmon (11), complicated urinary tract infections (7), bronchopneumonia (7), chronic osteomyelitis in exacerbation (8), chronic prostatitis in exacerbation (5), lower urinary tract infections (3), chronic otitis media (3), acute otitis (3), acute bronchitis (1), lung abscess (2) or liver abscess (1). Pathogens included Pseudomonas aeruginosa (24), Haemophilus influenzae (16), Proteus mirabilis (6), Escherichia coli (6), Enterobacter cloacae (6), Providencia stuartii (2), Serratia marcescens (2), Citrobacter diversus (1), Salmonella enteritidis (1), Acinetobacter anitratus (1), Staphylococcus aureus (1) and Streptococcus pneumoniae (1). In 35 patients (53%), several aggravating factors coexisted. MICs of ofloxacin ranged from less than or equal to 0.06 to 2 mg/L. Clinically, 65% of the patients were considered as cured, 17% improved and 18% failed to respond. Bacteriologically, pathogens were eradicated in 62%, persisted in 16% and relapsed in 22%. Adverse reactions included gastrointestinal disturbances (4), rash plus facial oedema (1), abnormal liver function (2) and leucopenia (1).
66例患者接受每日400至800毫克的氧氟沙星治疗，疗程为10天至6个月。他们患有慢性支气管炎急性加重（15例）、软组织蜂窝织炎（11例）、复杂性尿路感染（7例）、支气管肺炎（7例）、慢性骨髓炎急性加重（8例）、慢性前列腺炎急性加重（5例）、下尿路感染（3例）、慢性中耳炎（3例）、急性中耳炎（3例）、急性支气管炎（1例）、肺脓肿（2例）或肝脓肿（1例）。病原体包括铜绿假单胞菌（24例）、流感嗜血杆菌（16例）、奇异变形杆菌（6例）、大肠埃希菌（6例）、阴沟肠杆菌（6例）、斯氏普罗威登斯菌（2例）、黏质沙雷菌（2例）、奇异柠檬酸杆菌（1例）、肠炎沙门菌（1例）、鲍曼不动杆菌（1例）、金黄色葡萄球菌（1例）和肺炎链球菌（1例）。35例患者（53%）存在多种加重因素。氧氟沙星的最低抑菌浓度范围为小于或等于0.06至2毫克/升。临床上，65%的患者被认为治愈，17%改善，18%无反应。细菌学上，62%的病原体被根除，16%持续存在，22%复发。不良反应包括胃肠道不适（4例）、皮疹伴面部水肿（1例）、肝功能异常（2例）和白细胞减少（1例）。
