Department of Pharmacy, University of Baluchistan, Quetta, Pakistan/Discipline of Social and Administrative Pharmacy, School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang, Malaysia.
Health Qual Life Outcomes. 2012 Aug 6;10:91. doi: 10.1186/1477-7525-10-91.
The study aims to assess Health Related Quality of Life (HRQoL) among Hepatitis B (HB) patients and to identify significant predictors of the HRQoL in HB patients of Quetta, Pakistan.
A cross sectional study by adopting European Quality of Life scale (EQ-5D) for the assessment of HRQoL was conducted. All registered HB patients attending two public hospitals in Quetta, Pakistan were approached for study. Descriptive statistics were used to describe demographic and disease related characteristics of the patients. HRQoL was scored using values adapted from the United Kingdom general population survey. EQ-5D scale scores were compared with Mann-Whitney and Kruskal-Wallis test. Standard multiple regression analysis was performed to identify predictors of HRQoL. All analyses were performed using SPSS v 16.0.
Three hundred and ninety HB patients were enrolled in the study. Majority of the participants (n = 126, 32.3%) were categorized in the age group of 18-27 years (36.07 ± 9.23). HRQoL was measured as poor in the current study patients (0.3498 ± 0.31785). The multivariate analysis revealed a significant model (F(10, 380) = 40.04, P < 0.001, adjusted r(2) = 0.401). Educational level (β = 0.399, p = 0.025) emerged as a positive predictor of HRQoL. Age, gender, occupation, income and locality were not predictive of better quality of life in HB patients.
Hepatitis B has an adverse affect on patients' well-being and over all HRQoL. The study findings implicate the need of health promotion among HB patients. Improving the educational status and imparting disease related information for the local population can results in better control and management of HB.
本研究旨在评估乙型肝炎（HB）患者的健康相关生活质量（HRQoL），并确定巴基斯坦奎达 HB 患者 HRQoL 的显著预测因素。
通过采用欧洲生活质量量表（EQ-5D）评估 HRQoL，进行了一项横断面研究。所有在巴基斯坦奎达的两家公立医院登记的 HB 患者均被纳入研究。采用描述性统计方法描述患者的人口统计学和疾病相关特征。使用来自英国一般人群调查的数值对 HRQoL 进行评分。使用 Mann-Whitney 和 Kruskal-Wallis 检验比较 EQ-5D 量表评分。采用标准多元回归分析确定 HRQoL 的预测因素。所有分析均使用 SPSS v 16.0 进行。
本研究共纳入 390 名 HB 患者。大多数参与者（n=126，32.3%）被归入 18-27 岁年龄组（36.07±9.23）。目前研究患者的 HRQoL 较差（0.3498±0.31785）。多变量分析显示，一个显著的模型（F（10, 380）=40.04，P<0.001，调整 r（2）=0.401）。教育水平（β=0.399，p=0.025）是 HRQoL 的积极预测因素。年龄、性别、职业、收入和所在地不是 HB 患者生活质量更好的预测因素。
乙型肝炎对患者的幸福感和整体 HRQoL 产生不利影响。研究结果表明，需要在 HB 患者中开展健康促进活动。提高教育水平并为当地居民提供疾病相关信息，可以更好地控制和管理 HB。
