Department of Psychiatry and Biobehavioral Sciences, University of California Los Angele, CA 90095, USA.
J Affect Disord. 2013 Apr 5;146(2):266-71. doi: 10.1016/j.jad.2012.06.038. Epub 2012 Aug 4.
Premenstrual dysphoric disorder (PMDD) is characterized by severe, negative mood symptoms during the luteal phase of each menstrual cycle. We recently reported that women with PMDD show a greater increase in relative glucose metabolism in the posterior cerebellum from the follicular to the luteal phase, as compared with healthy women, and that the phase-related increase is proportional to PMDD symptom severity. We extended this work with a study of brain structure in PMDD.
High-resolution magnetic resonance imaging (MRI) scans were obtained from 12 women with PMDD and 13 healthy control subjects (whole-brain volume-corrected p<.05). Voxel-based morphometry was used to assess group differences in cerebral grey-matter volume (GMV), using a statistical criterion of p<.05, correcting for multiple comparisons in the whole-brain volume.
PMDD subjects had greater GMV than controls in the posterior cerebellum but not in any other brain area. Age was negatively correlated with GMV within this region in healthy women, but not in women with PMDD. The group difference in GMV was significant for women over age 30(p=.0002) but not younger participants (p>.1).
PMDD appears to be associated with reduced age-related loss in posterior cerebellar GMV. Although the mechanism underlying this finding is unclear, cumulative effects of symptom-related cerebellar activity may be involved.
经前烦躁障碍（PMDD）的特征是在每个月经周期的黄体期出现严重的负面情绪症状。我们最近报道，与健康女性相比，PMDD 女性在后脑小脑的相对葡萄糖代谢从卵泡期到黄体期有更大的增加，并且与 PMDD 症状严重程度成正比。我们通过对 PMDD 脑结构的研究扩展了这项工作。
从 12 名 PMDD 女性和 13 名健康对照组（全脑体积校正后 p<.05）中获得高分辨率磁共振成像（MRI）扫描。使用体素形态计量学来评估大脑灰质体积（GMV）的组间差异，使用全脑体积校正的统计学标准 p<.05。
PMDD 患者的后脑 GMV 高于对照组，但在其他脑区无差异。在健康女性中，年龄与该区域内的 GMV 呈负相关，但在 PMDD 女性中则无相关性。在年龄超过 30 岁的女性中（p=.0002），GMV 的组间差异显著，但在年龄较小的参与者中则不显著（p>.1）。
PMDD 似乎与后脑 GMV 的年龄相关丢失减少有关。尽管这一发现的机制尚不清楚，但与症状相关的小脑活动的累积效应可能与此有关。
