N-取代的 5-氯-6-苯基哒嗪-3(2H)-酮：合成、对小菜蛾（Plutella xylostella (L.)）的杀虫活性及 SAR 研究。
N-substituted 5-chloro-6-phenylpyridazin-3(2H)-ones: synthesis, insecticidal activity against Plutella xylostella (L.) and SAR study.
机构信息
State Key Laboratory Breeding Base of Green Pesticides and Agricultural Bioengineering, Key Laboratory of Green Pesticides and Agricultural Bioengineering, Ministry of Education, Guizhou University, Guiyang, China.
出版信息
Molecules. 2012 Aug 6;17(8):9413-20. doi: 10.3390/molecules17089413.
A series of N-substituted 5-chloro-6-phenylpyridazin-3(2H)-one derivatives were synthesized based on our previous work; all compounds were characterized by spectral data and tested for in vitro insecticidal activity against Plutella xylostella. The results showed that the synthesized pyridazin-3(2H)-one compounds possessed good insecticidal activities, especially the compounds 4b, 4d, and 4h which showed > 90% activity at 100 mg/L. The structure-activity relationships (SAR) for these compounds were also discussed.
基于我们之前的工作，合成了一系列 N-取代的 5-氯-6-苯基哒嗪-3(2H)-酮衍生物；所有化合物均通过光谱数据进行了表征，并测试了对小菜蛾的体外杀虫活性。结果表明，所合成的哒嗪-3(2H)-酮类化合物具有良好的杀虫活性，尤其是化合物 4b、4d 和 4h，在 100mg/L 时活性超过 90%。还讨论了这些化合物的构效关系(SAR)。
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