State Key Laboratory Breeding Base of Green Pesticides and Agricultural Bioengineering, Key Laboratory of Green Pesticides and Agricultural Bioengineering, Ministry of Education, Guizhou University, Guiyang, China.
Molecules. 2012 Aug 6;17(8):9413-20. doi: 10.3390/molecules17089413.
A series of N-substituted 5-chloro-6-phenylpyridazin-3(2H)-one derivatives were synthesized based on our previous work; all compounds were characterized by spectral data and tested for in vitro insecticidal activity against Plutella xylostella. The results showed that the synthesized pyridazin-3(2H)-one compounds possessed good insecticidal activities, especially the compounds 4b, 4d, and 4h which showed > 90% activity at 100 mg/L. The structure-activity relationships (SAR) for these compounds were also discussed.
基于我们之前的工作，合成了一系列 N-取代的 5-氯-6-苯基哒嗪-3(2H)-酮衍生物；所有化合物均通过光谱数据进行了表征，并测试了对小菜蛾的体外杀虫活性。结果表明，所合成的哒嗪-3(2H)-酮类化合物具有良好的杀虫活性，尤其是化合物 4b、4d 和 4h，在 100mg/L 时活性超过 90%。还讨论了这些化合物的构效关系(SAR)。
