Dai Hong, Li Gang, Chen Jia, Shi Yujun, Ge Shushan, Fan Chongguang, He Haibing
College of Chemistry and Chemical Engineering, Nantong University, Nantong 226019, People's Republic of China.
College of Chemistry and Chemical Engineering, Nantong University, Nantong 226019, People's Republic of China.
Bioorg Med Chem Lett. 2016 Aug 1;26(15):3818-21. doi: 10.1016/j.bmcl.2016.04.094. Epub 2016 May 7.
A new library of 1,3,4-thiadiazole-containing pyrazole oximes was designed and synthesized. Their acaricidal and insecticidal activities were evaluated. Bioassay results indicated that some target compounds exhibited good acaricidal and insecticidal properties. Especially, compound 8m had 80% acaricidal activity against Tetranychus cinnabarinus at the concentration of 50μg/mL, compound 8f displayed 100% insecticidal activities against Aphis craccivora at the concentration of 50μg/mL, compounds 8r and 8w showed 100% insecticidal activities against Plutella xylostella at the concentration of 50μg/mL. Furthermore, compounds 8r (LC50=19.61μg/mL) and 8w (LC50=9.78μg/mL) possessed comparable or even better insecticidal activities than the control Pyridalyl (LC50=17.40μg/mL) against P. xylostella.
设计并合成了一个含1,3,4-噻二唑的吡唑肟新库。对它们的杀螨和杀虫活性进行了评估。生物测定结果表明，一些目标化合物表现出良好的杀螨和杀虫性能。特别是，化合物8m在50μg/mL浓度下对朱砂叶螨具有80%的杀螨活性，化合物8f在50μg/mL浓度下对豆蚜表现出100%的杀虫活性，化合物8r和8w在50μg/mL浓度下对小菜蛾表现出100%的杀虫活性。此外，化合物8r（LC50=19.61μg/mL）和8w（LC50=9.78μg/mL）对小菜蛾的杀虫活性与对照药剂唑虫酰胺（LC50=17.40μg/mL）相当甚至更好。
