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The elusive source of myofibroblasts: problem solved?

作者信息

Duffield Jeremy S

出版信息

Nat Med. 2012 Aug;18(8):1178-80. doi: 10.1038/nm.2867.

DOI:10.1038/nm.2867
PMID:22869183
Abstract
摘要

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The elusive source of myofibroblasts: problem solved?肌成纤维细胞难以捉摸的来源:问题解决了吗?
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Balanced Wnt/Dickkopf-1 signaling by mesenchymal vascular progenitor cells in the microvascular niche maintains distal lung structure and function.间质血管祖细胞在微血管龛中通过平衡的 Wnt/ Dickkopf-1 信号维持远端肺结构和功能。
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本文引用的文献

1
Lineage tracing and genetic ablation of ADAM12(+) perivascular cells identify a major source of profibrotic cells during acute tissue injury.谱系追踪和 ADAM12(+)血管周细胞的基因敲除鉴定出急性组织损伤期间成纤维细胞的主要来源。
Nat Med. 2012 Aug;18(8):1262-70. doi: 10.1038/nm.2848. Epub 2012 Jul 29.
2
Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis.肌成纤维细胞在肝纤维化消退过程中会恢复为非激活表型。
Proc Natl Acad Sci U S A. 2012 Jun 12;109(24):9448-53. doi: 10.1073/pnas.1201840109. Epub 2012 May 7.
3
A pericyte origin of spinal cord scar tissue.
慢性肺部疾病中失调的血管生成:肺间充质祖细胞的潜在作用(2017年格罗弗会议系列)
Pulm Circ. 2018 Jan-Mar;8(1):2045893217739807. doi: 10.1177/2045893217739807. Epub 2017 Oct 17.
4
Identification of Novel Fibrosis Modifiers by In Vivo siRNA Silencing.通过体内RNA干扰沉默技术鉴定新型纤维化调节因子
Mol Ther Nucleic Acids. 2017 Jun 16;7:314-323. doi: 10.1016/j.omtn.2017.04.014. Epub 2017 Apr 20.
5
Disruption of lineage specification in adult pulmonary mesenchymal progenitor cells promotes microvascular dysfunction.成年肺间充质祖细胞谱系特化的破坏会促进微血管功能障碍。
J Clin Invest. 2017 Jun 1;127(6):2262-2276. doi: 10.1172/JCI88629. Epub 2017 May 2.
6
Pericytes: A newly recognized player in wound healing.周细胞:伤口愈合中一个新发现的参与者。
Wound Repair Regen. 2016 Mar;24(2):204-14. doi: 10.1111/wrr.12415. Epub 2016 Mar 10.
7
Impaired Cav-1 expression in SSc mesenchymal cells upregulates VEGF signaling: a link between vascular involvement and fibrosis.系统性硬化症间充质细胞中Cav-1表达受损上调血管内皮生长因子信号传导:血管受累与纤维化之间的联系
Fibrogenesis Tissue Repair. 2014 Sep 15;7:13. doi: 10.1186/1755-1536-7-13. eCollection 2014.
8
Acute interstitial nephritis - a reappraisal and update.急性间质性肾炎——重新评估与更新
Clin Nephrol. 2014 Sep;82(3):149-62. doi: 10.5414/cn108386.
9
The role of mouse strain differences in the susceptibility to fibrosis: a systematic review.小鼠品系差异在纤维化易感性中的作用:一项系统综述。
Fibrogenesis Tissue Repair. 2013 Sep 25;6(1):18. doi: 10.1186/1755-1536-6-18.
10
Type-1 pericytes participate in fibrous tissue deposition in aged skeletal muscle.1 型周细胞参与衰老骨骼肌中纤维组织的沉积。
Am J Physiol Cell Physiol. 2013 Dec 1;305(11):C1098-113. doi: 10.1152/ajpcell.00171.2013. Epub 2013 Sep 25.
脊髓瘢痕组织的周细胞起源。
Science. 2011 Jul 8;333(6039):238-42. doi: 10.1126/science.1203165.
4
Pericytes regulate the blood-brain barrier.周细胞调节血脑屏障。
Nature. 2010 Nov 25;468(7323):557-61. doi: 10.1038/nature09522. Epub 2010 Oct 13.
5
Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis.命运追踪揭示了肾脏纤维化中肌成纤维细胞的周细胞而非上皮细胞起源。
Am J Pathol. 2010 Jan;176(1):85-97. doi: 10.2353/ajpath.2010.090517. Epub 2009 Dec 11.
6
Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases.常见且独特的机制调节各种纤维增生性疾病中的纤维化。
J Clin Invest. 2007 Mar;117(3):524-9. doi: 10.1172/JCI31487.
7
Origin of fibroblasts in wound healing. An autoradiographic study of inhibition of cellular proliferation by local x-irradiation.伤口愈合中纤维母细胞的起源。局部X线照射对细胞增殖抑制作用的放射自显影研究。
Ann Surg. 1963 Mar;157(3):453-67. doi: 10.1097/00000658-196303000-00018.
8
Studies on blood capillaries. I. General organization of blood capillaries in muscle.毛细血管研究。I. 肌肉中毛细血管的一般结构
J Cell Biol. 1968 May;37(2):244-76. doi: 10.1083/jcb.37.2.244.
9
Wound healing and collagen formation. VI. The origin of the wound fibroblast studied in parabiosis.伤口愈合与胶原蛋白形成。VI. 联体生活中研究的伤口成纤维细胞的起源。
J Cell Biol. 1970 Mar;44(3):645-54. doi: 10.1083/jcb.44.3.645.
10
Hepatic lipocytes: the principal collagen-producing cells of normal rat liver.肝星状细胞:正常大鼠肝脏中主要的胶原生成细胞。
Proc Natl Acad Sci U S A. 1985 Dec;82(24):8681-5. doi: 10.1073/pnas.82.24.8681.