Cosmetic Ingredient Review, 1101 17th Street, NW, Suite 412, Washington, DC 20036, USA.
Int J Toxicol. 2012 Jul-Aug;31(4 Suppl):5S-76S. doi: 10.1177/1091581812447203.
The CIR Expert Panel assessed the safety of dicarboxylic acids and their salts and esters as used in cosmetics. Most dicarboxylic acids function in cosmetics as pH adjusters or fragrance ingredients, but the functions of most of the salts in cosmetics are not reported. Some of the esters function as skin conditioning or fragrance ingredients, plasticizers, solvents, or emollients. The Expert Panel noted gaps in the available safety data for some of the dicarboxylic acid and their salts and esters in this safety assessment. The available data on many of the ingredients are sufficient, however, and similar structural activity relationships, biologic functions, and cosmetic product usage suggest that the available data may be extrapolated to support the safety of the entire group. The Panel concluded that the ingredients named in this report are safe in the present practices of use and concentration.
CIR 专家小组评估了在化妆品中使用的二羧酸及其盐和酯的安全性。大多数二羧酸在化妆品中用作 pH 值调节剂或香料成分，但化妆品中大多数盐的功能并未报告。一些酯类作为皮肤调理剂或香料成分、增塑剂、溶剂或润肤剂。专家小组注意到在本次安全性评估中，一些二羧酸及其盐和酯的可用安全性数据存在差距。然而，关于许多成分的可用数据是足够的，并且相似的结构活性关系、生物功能和化妆品产品使用情况表明，可用数据可以推断出整个组的安全性。小组得出结论，报告中提到的成分在目前的使用和浓度下是安全的。
