Cosmetic Ingredient Review, 1101 17th Street, NW, Suite, 412, Washington, DC 20036, USA.
Int J Toxicol. 2011 Dec;30(6 Suppl):228S-69S. doi: 10.1177/1091581811428980.
Pelargonic acid and its esters function as skin-conditioning agents in cosmetics. Molecular weight (mw) and octanol-water partition coefficient data suggest that dermal penetration is possible. The biohandling of branched-chain fatty acids is not the same as for straight-chain fatty acids, but the differences are not significant to the conclusion that they all are readily metabolized to nontoxic moieties. Limited data suggested that the penetration of other ingredients may be enhanced if these ingredients are present in the same formulation. These ingredients are not significant oral or dermal toxicants in animal studies. They are not reproductive/developmental toxicants or genotoxic/carcinogenic in animal studies. The available data suggested that product formulations containing these ingredients would be nonirritating and nonsensitizing to human skin, but formulators were cautioned to consider the penetration enhancement potential. The Cosmetic Ingredient Review (CIR) Expert Panel concluded that these ingredients are safe in the present practices of use and concentration.
壬二酸及其酯类作为化妆品中的皮肤调理剂。分子量（mw）和辛醇-水分配系数数据表明，它们有可能经皮渗透。支链脂肪酸的生物处理与直链脂肪酸不同，但这些差异对于它们都容易代谢为无毒部分的结论并不重要。有限的数据表明，如果这些成分存在于同一配方中，其他成分的渗透可能会增强。这些成分在动物研究中不是口腔或皮肤的有毒物质，也不是生殖/发育毒物或遗传毒性/致癌性。现有数据表明，含有这些成分的产品配方对人体皮肤无刺激性和致敏性，但配方师被警告要考虑渗透增强的潜力。化妆品成分评估专家小组（CIR）认为，这些成分在目前的使用和浓度下是安全的。
