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咪达唑仑诱发的急性肌张力障碍被地西泮逆转。

Midazolam-induced acute dystonia reversed by diazepam.

作者信息

Komur Mustafa, Arslankoylu Ali Ertug, Okuyaz Cetin

机构信息

Department of Pediatric Neurology, Mersin University School of Medicine, Mersin, Turkey.

出版信息

J Anaesthesiol Clin Pharmacol. 2012 Jul;28(3):368-70. doi: 10.4103/0970-9185.98346.

DOI:10.4103/0970-9185.98346
PMID:22869948
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3409951/
Abstract

Midazolam can induce acute dystonia in childhood. We report the development of acute dystonia in a 6-year-old girl after receiving midazolam as a sedative. Dystonic contractions persisted despite flumazenil and biperiden lactate injections and the patient was treated with diazepam. Acute dystonia was rapidly abolished after the administration of diazepam intravenously. Diazepam may be an effective treatment option in patients who are unresponsive to flumazenil.

摘要

咪达唑仑可在儿童期诱发急性肌张力障碍。我们报告了一名6岁女孩在接受咪达唑仑作为镇静剂后发生急性肌张力障碍的情况。尽管注射了氟马西尼和乳酸比哌立登，但肌张力障碍性收缩仍持续存在，该患者接受了地西泮治疗。静脉注射地西泮后，急性肌张力障碍迅速消失。对于对氟马西尼无反应的患者，地西泮可能是一种有效的治疗选择。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a60/3409951/4161b1207db0/JOACP-28-368-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a60/3409951/4161b1207db0/JOACP-28-368-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a60/3409951/4161b1207db0/JOACP-28-368-g001.jpg

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Midazolam-induced acute dystonia reversed by diazepam.咪达唑仑诱发的急性肌张力障碍被地西泮逆转。
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Pharmacokinetics of midazolam tablet in different Chinese ethnic groups.中各族群人群中咪达唑仑片的药代动力学。
J Clin Pharm Ther. 2011 Jun;36(3):406-11. doi: 10.1111/j.1365-2710.2010.01178.x. Epub 2010 Aug 24.
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Midazolam-induced extrapyramidal side effects.咪达唑仑引起的锥体外系副作用。
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Subcutaneous midazolam as a cause of extrapyramidal side effects in a patient with prostate cancer.皮下注射咪达唑仑导致一名前列腺癌患者出现锥体外系副作用。
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In response to: Midazolam-induced acute dystonia reversed by diazepam.回应：咪达唑仑诱发的急性肌张力障碍被地西泮逆转。
J Anaesthesiol Clin Pharmacol. 2013 Apr;29(2):268-9. doi: 10.4103/0970-9185.111732.
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GABA(A) receptor diversity and pharmacology.γ-氨基丁酸A（GABA(A)）受体的多样性与药理学
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Dystonia genotypes, phenotypes, and classification.肌张力障碍的基因型、表型及分类。
Adv Neurol. 2004;94:101-7.
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The midazolam-induced paradox phenomenon is reversible by flumazenil. Epidemiology, patient characteristics and review of the literature.咪达唑仑诱导的矛盾现象可被氟马西尼逆转。流行病学、患者特征及文献综述。
Eur J Anaesthesiol. 2001 Dec;18(12):789-97. doi: 10.1046/j.1365-2346.2001.00922.x.
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