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来自桑黄培养 broth 的神经氨酸酶抑制剂。 （注：broth 常见释义为“肉汤”“培养液”等，这里结合语境翻译为“培养液”更合适）

Neuraminidase Inhibitors from the Culture Broth of Phellinus linteus.

作者信息

Yeom Ji-Hee, Lee In-Kyoung, Ki Dae-Won, Lee Myeong-Seok, Seok Soon-Ja, Yun Bong-Sik

机构信息

Division of Biotechnology, College of Environmental and Bioresource Sciences, Chonbuk National University, Iksan 570-752, Korea.

出版信息

Mycobiology. 2012 Jun;40(2):142-4. doi: 10.5941/MYCO.2012.40.2.142. Epub 2012 Jun 29.

DOI:10.5941/MYCO.2012.40.2.142
PMID:22870059
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3408306/
Abstract

During the search for neuraminidase inhibitors from medicinal fungi, we found that the culture broth of Phellinus linteus exhibited potent inhibitory activity. Solvent partition, Sephadex LH-20 column chromatography, and high-performance liquid chromatography (HPLC) were performed for purification of two active substances from the culture broth. According to (1)H NMR measurements and comparison of HPLC retention times with those of authentic compounds, their chemical structures were identified as hispidin and hypholomine B. Compounds (hispidin) 1 and 2 (hypholomine B) inhibited neuraminidase, with IC(50) values of 13.1 and 0.03 µM, respectively.

摘要

在从药用真菌中寻找神经氨酸酶抑制剂的过程中，我们发现桑黄的培养液具有很强的抑制活性。采用溶剂分配、葡聚糖凝胶LH - 20柱色谱和高效液相色谱（HPLC）从培养液中纯化出两种活性物质。根据¹H NMR测量以及HPLC保留时间与标准化合物的比较，确定它们的化学结构分别为漆斑菌素和真菌氨酸B。化合物1（漆斑菌素）和2（真菌氨酸B）对神经氨酸酶有抑制作用，IC₅₀值分别为13.1和0.03 μM。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff72/3408306/bd501ca3bab9/mb-40-142-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff72/3408306/26c13b216f50/mb-40-142-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff72/3408306/bd501ca3bab9/mb-40-142-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff72/3408306/26c13b216f50/mb-40-142-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff72/3408306/bd501ca3bab9/mb-40-142-g002.jpg

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