Arya Aditya, Al-Waili Noori
Heath and Wellness Center, Mount Vernon, New York, USA.
J Clin Med Res. 2012 Aug;4(4):292-4. doi: 10.4021/jocmr936w. Epub 2012 Jul 20.
There is an association between insulin analogues, glargine, lispro and aspart and the incidence of malignancies. A 76 year-old female patient with history of diabetes, hypertension and hyperlipidemia presented with flank pain after using insulin Levemir as part of her management. CT abdomen revealed pancreatic mass and endoscopic ultrasound- guided FNA aspiration biopsy showed pancreatic adenocarcinoma. It was not clear whether the insulin analogue initiated the tumor or helped the growth of pre-existing malignant foci. Then we concluded that case presented raises an indicator of possible association between using insulin analogue and initiation of malignancies, or stimulation of malignant foci.
胰岛素类似物、甘精胰岛素、赖脯胰岛素和门冬胰岛素与恶性肿瘤的发生率之间存在关联。一名76岁女性患者，有糖尿病、高血压和高脂血症病史，在使用来得时胰岛素作为治疗一部分后出现侧腹痛。腹部CT显示胰腺肿块，内镜超声引导下细针穿刺活检显示为胰腺腺癌。尚不清楚胰岛素类似物是引发了肿瘤还是促进了已存在恶性病灶的生长。然后我们得出结论，该病例提示了使用胰岛素类似物与恶性肿瘤发生或恶性病灶刺激之间可能存在关联的一个指标。
