Zhai Jun, Zhai Xiao-dong
Oral and Maxillofacial Surgery, Changyi People's Hospital, Shandong Province, Changyi 261300, China.
Zhonghua Zheng Xing Wai Ke Za Zhi. 2012 May;28(3):168-71.
To investigate the therapeutic effect of combined injection of pingyangmycin (PYM) & dexame thasone (DXM) for the treatment of maxillofacial and cervical venous malformations.
From August 1995 to October 2008, 116 cases with maxillofacial and cervical venous malformations were retrospectively analyzed. The injection dilute was made with PYM 8 mg, DXM 10 mg and 2% lidocaine 2.0 ml (PYM 2 mg/ml). The PYM diluent 1.0-4.0 ml (including the PYM 2-8 mg) was injected into the tumor according to the patients age, tumor size and location. For children, PYM 2-4 mg was injected for one treatment. The needle should be inserted into tumor perpendicularly or from the edge of tumor. After withdrawing blood, the drug was injected into the tumor slowly. The injection could be repeated every 7-10 days. The clinical signs were recorded; ultrasonography and chest X-ray were performed to evaluate the therapeutic effect.
1-5 treatments of injection were performed in the 116 patients. The tumor shrinked and disappeared after treatment with PYM 2-40 mg and DXM 5-50 mg. The patients were followed up for 3-5 years with no occurrence and complication.
It's safe, effective and practical to treat maxillofacial and cervical venous malformations by combined injection of PYM and DXM. The cosmetic appearance and function can be preserved at the most.
探讨平阳霉素（PYM）与地塞米松（DXM）联合注射治疗颌面部及颈部静脉畸形的疗效。
回顾性分析1995年8月至2008年10月间116例颌面部及颈部静脉畸形患者。注射用稀释液由8mg平阳霉素、10mg地塞米松和2.0ml 2%利多卡因配制而成（平阳霉素浓度为2mg/ml）。根据患者年龄、肿瘤大小及部位，将1.0 - 4.0ml平阳霉素稀释液（含平阳霉素2 - 8mg）注入肿瘤内。儿童每次治疗注射平阳霉素2 - 4mg。进针应垂直于肿瘤或从肿瘤边缘进针，回抽有血后，将药物缓慢注入肿瘤内。每7 - 10天可重复注射。记录临床症状；行超声及胸部X线检查评估治疗效果。
116例患者均接受了1 - 5次注射治疗。经2 - 40mg平阳霉素和5 - 50mg地塞米松治疗后，肿瘤缩小或消失。患者随访3 - 5年，无复发及并发症发生。
平阳霉素与地塞米松联合注射治疗颌面部及颈部静脉畸形安全、有效、实用，最大程度保留了外观及功能。
