评估酮和 1,2-二酮的一些经典腙类化合物作为抗利什曼原虫、抗菌和抗真菌剂的效果。
Evaluation of some classical hydrazones of ketones and 1,2-diketones as antileishmanial, antibacterial and antifungal agents.
机构信息
Institute of Biochemistry, University of Baluchistan, Quetta, Pakistan.
出版信息
Arch Pharm Res. 2012 Jun;35(6):1009-13. doi: 10.1007/s12272-012-0608-7. Epub 2012 Jun 30.
PMID:22870810
Abstract
The paper describes the synthesis and antimicrobial (antileishmanial, antibacterial and antifungal) activity of some classical hydrazones of benzophenones and of 1,2-diketones. N-(Diaryl) acyl derivatives of these hydrazones have also been synthesized and evaluated. 4,4,-Demthoxybenzil monohydrazone and 4,4'-dimethoxybenzophenone hydrazone showed significant antileishmanial activity. The effect of substituents on the bioactivity is discussed.
摘要
本文描述了一些苯甲酮和 1,2-二酮类经典腙的合成及其抗菌（抗利什曼原虫、抗细菌和抗真菌）活性。还合成并评价了这些腙的 N-(二芳基)酰基衍生物。4,4'-二甲氧基苯甲酰单腙和 4,4'-二甲氧基二苯甲酮腙表现出显著的抗利什曼原虫活性。讨论了取代基对生物活性的影响。
Zotero 插件