IF1 重新编程能量代谢并发出癌症的致癌表型信号。

IF1 reprograms energy metabolism and signals the oncogenic phenotype in cancer.

出版信息

Cell Cycle. 2012 Aug 15;11(16):2963-4. doi: 10.4161/cc.21387. Epub 2012 Aug 8.

DOI:10.4161/cc.21387

PMID:22871729

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3442896/

Abstract

Comment on: Formentini L, et al. Mol Cell 2012; 45:731-42.

摘要

Formentini L，等。分子细胞 2012；45：731-42。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5da8/3442896/d1185ccbdada/cc-11-2963-g1.jpg

相似文献

IF1 reprograms energy metabolism and signals the oncogenic phenotype in cancer.

Cell Cycle. 2012 Aug 15;11(16):2963-4. doi: 10.4161/cc.21387. Epub 2012 Aug 8.

The ATPase Inhibitory Factor 1 (IF1): A master regulator of energy metabolism and of cell survival.

Biochim Biophys Acta. 2016 Aug;1857(8):1167-1182. doi: 10.1016/j.bbabio.2016.02.004. Epub 2016 Feb 12.

Regulation of cellular energy metabolism.

J Membr Biol. 1982;70(1):1-14. doi: 10.1007/BF01871584.

The F1Fo-ATPase inhibitor, IF1, is a critical regulator of energy metabolism in cancer cells.

Biochem Soc Trans. 2021 Apr 30;49(2):815-827. doi: 10.1042/BST20200742.

ATP synthesis in mitochondria.

Eur J Biochem. 1993 Dec 15;218(3):759-67. doi: 10.1111/j.1432-1033.1993.tb18431.x.

IF1, the endogenous regulator of the F(1)F(o)-ATPsynthase, defines mitochondrial volume fraction in HeLa cells by regulating autophagy.

Biochim Biophys Acta. 2009 May;1787(5):393-401. doi: 10.1016/j.bbabio.2009.02.023. Epub 2009 Mar 5.

[Current theories on the mechanism of energy coupling in mitochondria].

Postepy Biochem. 1985;31(1):5-28.

The role of the ATPase inhibitor factor 1 (IF) in cancer cells adaptation to hypoxia and anoxia.

Biochim Biophys Acta Bioenerg. 2018 Feb;1859(2):99-109. doi: 10.1016/j.bbabio.2017.10.007. Epub 2017 Oct 31.

Generation of mitochondrial reactive oxygen species is controlled by ATPase inhibitory factor 1 and regulates cognition.

PLoS Biol. 2021 May 13;19(5):e3001252. doi: 10.1371/journal.pbio.3001252. eCollection 2021 May.

Early Defense Responses Involved in Mitochondrial Energy Metabolism and Reactive Oxygen Species Accumulation in Harvested Muskmelons Infected by Trichothecium roseum.

J Agric Food Chem. 2019 Apr 17;67(15):4337-4345. doi: 10.1021/acs.jafc.8b06333. Epub 2019 Apr 4.

引用本文的文献

The ATPase Inhibitory Factor 1 (IF1) Contributes to the Warburg Effect and Is Regulated by Its Phosphorylation in S39 by a Protein Kinase A-like Activity.

Cancers (Basel). 2024 Feb 29;16(5):1014. doi: 10.3390/cancers16051014.

The Mitochondrial ATP Synthase/IF1 Axis in Cancer Progression: Targets for Therapeutic Intervention.

Cancers (Basel). 2023 Jul 25;15(15):3775. doi: 10.3390/cancers15153775.

The Multifaceted ATPase Inhibitory Factor 1 (IF1) in Energy Metabolism Reprogramming and Mitochondrial Dysfunction: A New Player in Age-Associated Disorders?

Antioxid Redox Signal. 2022 Aug;37(4-6):370-393. doi: 10.1089/ars.2021.0137. Epub 2022 Jan 4.

Links between mitochondrial retrograde response and mitophagy in pathogenic cell signalling.

Cell Mol Life Sci. 2021 Apr;78(8):3767-3775. doi: 10.1007/s00018-021-03770-5. Epub 2021 Feb 23.

Overexpression of native IF1 downregulates glucose-stimulated insulin secretion by pancreatic INS-1E cells.

Sci Rep. 2020 Jan 31;10(1):1551. doi: 10.1038/s41598-020-58411-x.

Reduction of the ATPase inhibitory factor 1 (IF) leads to visual impairment in vertebrates.

Cell Death Dis. 2018 Jun 4;9(6):669. doi: 10.1038/s41419-018-0578-x.

ATPase inhibitory factor 1 expression is an independent prognostic factor in non-small cell lung cancer.

Am J Cancer Res. 2016 May 1;6(5):1141-8. eCollection 2016.

Changes in glycoprotein expression between primary breast tumour and synchronous lymph node metastases or asynchronous distant metastases.

Clin Proteomics. 2015 May 12;12(1):13. doi: 10.1186/s12014-015-9084-7. eCollection 2015.

Metabolic control of cancer cell stemness: Lessons from iPS cells.

Cell Cycle. 2015;14(24):3801-11. doi: 10.1080/15384101.2015.1022697.

Hitting the Bull's-Eye in Metastatic Cancers-NSAIDs Elevate ROS in Mitochondria, Inducing Malignant Cell Death.

Pharmaceuticals (Basel). 2015 Feb 13;8(1):62-106. doi: 10.3390/ph8010062.

本文引用的文献

Assessing actual contribution of IF1, inhibitor of mitochondrial FoF1, to ATP homeostasis, cell growth, mitochondrial morphology, and cell viability.

J Biol Chem. 2012 May 25;287(22):18781-7. doi: 10.1074/jbc.M112.345793. Epub 2012 Apr 9.

The mitochondrial ATPase inhibitory factor 1 triggers a ROS-mediated retrograde prosurvival and proliferative response.

Mol Cell. 2012 Mar 30;45(6):731-42. doi: 10.1016/j.molcel.2012.01.008. Epub 2012 Feb 16.

Post-transcriptional regulation of the mitochondrial H(+)-ATP synthase: a key regulator of the metabolic phenotype in cancer.

Biochim Biophys Acta. 2011 Jun;1807(6):543-51. doi: 10.1016/j.bbabio.2010.10.016. Epub 2010 Oct 27.

Up-regulation of the ATPase inhibitory factor 1 (IF1) of the mitochondrial H+-ATP synthase in human tumors mediates the metabolic shift of cancer cells to a Warburg phenotype.

J Biol Chem. 2010 Aug 13;285(33):25308-13. doi: 10.1074/jbc.M110.146480. Epub 2010 Jun 9.

The tumor suppressor function of mitochondria: translation into the clinics.

Biochim Biophys Acta. 2009 Dec;1792(12):1145-58. doi: 10.1016/j.bbadis.2009.01.006. Epub 2009 Jan 23.

Transcriptional paradigms in mammalian mitochondrial biogenesis and function.

Physiol Rev. 2008 Apr;88(2):611-38. doi: 10.1152/physrev.00025.2007.

How the regulatory protein, IF(1), inhibits F(1)-ATPase from bovine mitochondria.

Proc Natl Acad Sci U S A. 2007 Oct 2;104(40):15671-6. doi: 10.1073/pnas.0707326104. Epub 2007 Sep 25.

Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria.

Cell. 2003 Nov 26;115(5):629-40. doi: 10.1016/s0092-8674(03)00926-7.

The structure of bovine F1-ATPase in complex with its regulatory protein IF1.

Nat Struct Biol. 2003 Sep;10(9):744-50. doi: 10.1038/nsb966. Epub 2003 Aug 17.

The ATP synthase--a splendid molecular machine.

Annu Rev Biochem. 1997;66:717-49. doi: 10.1146/annurev.biochem.66.1.717.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验

IF1 重新编程能量代谢并发出癌症的致癌表型信号。

IF1 reprograms energy metabolism and signals the oncogenic phenotype in cancer.

出版信息

评论

相似文献

引用本文的文献

本文引用的文献

文献AI研究员

用中文搜PubMed

文档翻译

Suppr 超能文献

相似文献

引用本文的文献

本文引用的文献