Angiogenesis and Brain Development Laboratory, Division of Basic Neuroscience, McLean Hospital/Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA.
Development. 2012 Sep;139(17):3136-41. doi: 10.1242/dev.078394.
Neuronal migration, a key event during brain development, remains largely unexplored in the mesencephalon, where dopaminergic (DA) and GABA neurons constitute two major neuronal populations. Here we study the migrational trajectories of DA and GABA neurons and show that they occupy ventral mesencephalic territory in a temporally and spatially specific manner. Our results from the Pitx3-deficient aphakia mouse suggest that pre-existing DA neurons modulate GABA neuronal migration to their final destination, providing novel insights and fresh perspectives concerning neuronal migration and connectivity in the mesencephalon in normal as well as diseased brains.
神经元迁移是大脑发育过程中的一个关键事件，但在中脑仍未得到充分研究，其中多巴胺能（DA）和 GABA 神经元构成了两个主要的神经元群体。在这里，我们研究了 DA 和 GABA 神经元的迁移轨迹，并表明它们以时间和空间特异性的方式占据腹侧中脑区域。我们在 Pitx3 缺陷型无眼畸形小鼠中的研究结果表明，预先存在的 DA 神经元调节 GABA 神经元向其最终目的地的迁移，为正常和患病大脑中的中脑神经元迁移和连接提供了新的见解和新视角。
