Department of Pathology, Tochigi Institute of Clinical Pathology, Tochigi, Japan.
Reprod Sci. 2012 Dec;19(12):1365-72. doi: 10.1177/1933719112450340. Epub 2012 Aug 7.
Ectopic endometrial tissue induces various reactions in surrounding tissues, such as the surface of the ovary and peritoneal cavity, leading to endometriosis. The aim of this study is to investigate the expression profile of extracellular matrix (ECM) and adhesion molecules in the early steps of development of experimental mouse endometriosis, specifically in peritoneum adjacent to endometrium transplants attached via autotransplantation. The endometriosis model was induced by autotransplantation of endometrium to peritoneal tissue. Peritoneal tissues adjacent to the transplant were obtained at 1, 4, and 7 days posttransplantation. The results showed that messenger RNA expression levels of most of the integrins, collagens, and other ECM reached a peak at 7 days posttransplantation. Uniquely, Lamc2 was significantly increased to its maximum level within 24 hours posttransplantation and may be strongly associated with initiation of the development of endometriosis. These data will be helpful in further investigations of the treatment of endometriosis.
异位子宫内膜组织在周围组织（如卵巢表面和腹腔）中引起各种反应，导致子宫内膜异位症。本研究旨在探讨细胞外基质（ECM）和黏附分子在实验性小鼠子宫内膜异位症早期发展阶段的表达谱，特别是在子宫内膜自体移植附着的腹膜组织附近。通过子宫内膜自体移植到腹膜组织中诱导子宫内膜异位症模型。在移植后 1、4 和 7 天获取移植附近的腹膜组织。结果表明，大多数整合素、胶原和其他 ECM 的信使 RNA 表达水平在移植后 7 天达到峰值。独特的是，Lamac2 在移植后 24 小时内显著增加到最大值，可能与子宫内膜异位症发展的启动密切相关。这些数据将有助于进一步研究子宫内膜异位症的治疗。
