Uchiide Ichiro, Ihara Tomomi, Sugamata Masao
Department of Obstetrics and Gynecology, Japanese Red Cross Hospital Omori, Tokyo, Japan.
Fertil Steril. 2002 Oct;78(4):782-6. doi: 10.1016/s0015-0282(02)03327-7.
To observe in detail the morphology of experimental rat endometriosis, specifically in peritoneum adjacent to uterine transplants attached via autotransplantation.
Light and electron microscopic study.
Tochigi Institute of Clinical Pathology, Japan.
ANIMAL(S): Female-SD rats maintained on a schedule of 12 hours of light and 12 hours of dark for 2 weeks.
INTERVENTION(S): Uterine transplants were attached to rat peritoneum via the surgical autotransplantation technique. The implanted area of peritoneum, including abdominal muscle, were excised from anesthetized rats at four (n = 10), seven (n = 10), and 14 (n = 10) days after uterine autotransplantation. The mesenteries were autotransplanted as a comparative control.
MAIN OUTCOME MEASURE(S): We examined the morphologic alterations of uterus-attached peritoneum following the time interval after the implantation.
RESULT(S): In rat endometriosis models, the stromal tissue of uterus-attached peritoneum showed proliferation and infiltration of mast cells, eosinophils, plasma cells, lymphocytes, and macrophages. These lesions increased with time after implantation; however, ultimately these infiltrating cells disappeared and proliferation declined.
CONCLUSION(S): Our findings suggest that uterine autotransplantation induces the infiltration of allergic inflammatory-related cells and proliferative lesions in peritoneal stroma attached endometrium. These data should prove useful for investigations of human endometriosis.
详细观察实验性大鼠子宫内膜异位症的形态，特别是在通过自体移植附着子宫移植片附近的腹膜中的形态。
光镜和电镜研究。
日本枥木临床病理研究所。
雌性SD大鼠，维持12小时光照和12小时黑暗的作息2周。
通过手术自体移植技术将子宫移植片附着于大鼠腹膜。在子宫自体移植后4天（n = 10）、7天（n = 10）和14天（n = 10），从麻醉的大鼠身上切除包括腹肌在内的植入腹膜区域。将肠系膜作为对照进行自体移植。
我们检查了植入后不同时间间隔子宫附着腹膜的形态学改变。
在大鼠子宫内膜异位症模型中，子宫附着腹膜的基质组织显示肥大细胞、嗜酸性粒细胞、浆细胞、淋巴细胞和巨噬细胞的增殖和浸润。这些病变在植入后随时间增加；然而，最终这些浸润细胞消失且增殖下降。
我们的研究结果表明，子宫自体移植诱导与过敏炎症相关细胞浸润以及附着子宫内膜的腹膜基质中的增殖性病变。这些数据对人类子宫内膜异位症的研究应是有用的。
