Breast Cancer Res Treat. 2012 Nov;136(1):309-12. doi: 10.1007/s10549-012-2172-8. Epub 2012 Jul 25.
Results from the recent meta-analysis suggested a favorable effect of dietary calcium and vitamin D levels on breast cancer risk. However, the relationship of dietary calcium and vitamin D levels with breast cancer risk is unclear. Thus, the dose-response relationship was assessed by restricted cubic spline model and multivariate random-effect meta-regression. Results suggested that women might suffer from the lowest risk of breast cancer with dietary calcium intake of about 600 mg/day, dietary vitamin D intake of about 400 IU/day, and serum vitamin D levels of about 30 ng/ml.
最近的荟萃分析结果表明，膳食钙和维生素 D 水平对乳腺癌风险有有利影响。然而，膳食钙和维生素 D 水平与乳腺癌风险的关系尚不清楚。因此，采用受限立方样条模型和多变量随机效应荟萃回归评估了剂量反应关系。结果表明，女性每天摄入约 600mg 的膳食钙、400IU 的膳食维生素 D 和 30ng/ml 的血清维生素 D，可能患乳腺癌的风险最低。
