Zhao Yan, Guo Chenyang, Hu Hongtao, Zheng Lin, Ma Junli, Jiang Li, Zhao Erjiang, Li Hailiang
Department of Radiology Intervention, Affiliated Tumor Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Department of Epidemiology and Biostatistics, Affiliated Tumor Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Oncotarget. 2017 Feb 7;8(6):10458-10469. doi: 10.18632/oncotarget.14432.
Previously reported findings on the association between folate intake or serum folate levels and esophageal cancer risk have been inconsistent. This study aims to summarize the evidence regarding these relationships using a dose-response meta-analysis approach. We performed electronic searches of the Pubmed, Medline and Cochrane Library electronic databases to identify studies examining the effect of folate on the risk of esophageal cancer. Ultimately, 19 studies were included in the meta-analysis. Summary odds ratios (ORs) were estimated using a random effects model. A linear regression analysis of the natural logarithm of the OR was carried out to assess the possible dose-response relationship between folate intake and esophageal cancer risk. The pooled ORs for esophageal cancer in the highest vs. lowest levels of dietary folate intake and serum folate were 0.63 (95% CI: 0.56-0.71) and 0.71 (95% CI: 0.55-0.92), respectively. The dose-response meta-analysis indicated that a 100 μg/day increment in dietary folate intake reduced the estimate risk of esophageal cancer by 12%. These findings suggest that dietary and serum folate exert a protective effect against esophageal carcinogenesis.
先前关于叶酸摄入量或血清叶酸水平与食管癌风险之间关联的研究结果并不一致。本研究旨在采用剂量反应荟萃分析方法总结有关这些关系的证据。我们对PubMed、Medline和Cochrane图书馆电子数据库进行了电子检索，以识别研究叶酸对食管癌风险影响的研究。最终，19项研究被纳入荟萃分析。使用随机效应模型估计汇总比值比（OR）。对OR的自然对数进行线性回归分析，以评估叶酸摄入量与食管癌风险之间可能的剂量反应关系。饮食叶酸摄入量和血清叶酸最高水平与最低水平相比，食管癌的汇总OR分别为0.63（95%CI：0.56-0.71）和0.71（95%CI：0.55-0.92）。剂量反应荟萃分析表明，饮食叶酸摄入量每天增加100μg可使食管癌估计风险降低12%。这些发现表明，饮食和血清叶酸对食管癌发生具有保护作用。
