Department of Oncology/Breast Surgery, Cancer Hospital & Breast Cancer Institute, Shanghai Medical College Institutes of Biomedical Sciences, Fudan University, 399 Ling-Ling Road, Shanghai 200032, China.
Cell Biochem Biophys. 2013 Jan;65(1):37-41. doi: 10.1007/s12013-012-9400-z.
We evaluated the clinical significance of the combined use of mammography + ultrasound as a new breast screening strategy. The inclusion criteria were: (1) females aged >40yrs; (2) breast cancer diagnosis by the breast image screening personnel at FUSCC; (3) screening by both ultrasound and mammography; (4) mammographic/sonographic images analyzed independently by different radiologists; and (5) follow-up for at least 1 year. Fifty-four women were enrolled. The analysis included diagnostic sensitivity of mammography, ultrasound, and mammography + ultrasound. The sensitivities of mammography and mammography + ultrasound were compared overall as well as among different age groups/breast densities. The screening sensitivity of mammography, ultrasound, and mammography + ultrasound was 79.6, 57.4, and 92.6 %, respectively. The difference between mammography and mammography + ultrasound was significant (P < 0.05). The benefit of including ultrasound with mammography as a new breast image screening strategy was found statistically significant in patients with dense breast on mammogram while it was non-significant in younger (<50 years) women. We, therefore, concluded that mammography + ultrasound increased the diagnostic sensitivity of breast screening; hence it was more desirable for women with dense breast on mammography.
我们评估了联合使用乳腺 X 线摄影+超声作为一种新的乳腺筛查策略的临床意义。纳入标准为：（1）年龄>40 岁的女性；（2）FUSCC 的乳腺影像筛查人员诊断为乳腺癌；（3）同时进行超声和乳腺 X 线摄影筛查；（4）乳腺 X 线摄影/超声图像由不同的放射科医生独立分析；（5）随访至少 1 年。共纳入 54 例女性。分析包括乳腺 X 线摄影、超声和乳腺 X 线摄影+超声的诊断灵敏度。比较了乳腺 X 线摄影和乳腺 X 线摄影+超声的总体及不同年龄组/乳腺密度的灵敏度。乳腺 X 线摄影、超声和乳腺 X 线摄影+超声的筛查灵敏度分别为 79.6%、57.4%和 92.6%。乳腺 X 线摄影与乳腺 X 线摄影+超声之间的差异具有统计学意义（P<0.05）。在乳腺 X 线摄影表现为致密乳腺的患者中，将超声与乳腺 X 线摄影联合作为一种新的乳腺影像筛查策略具有显著获益，而在年龄较小（<50 岁）的女性中获益则不显著。因此，我们得出结论，乳腺 X 线摄影+超声提高了乳腺筛查的诊断灵敏度；因此，对于乳腺 X 线摄影表现为致密乳腺的女性更为理想。
