圆叶筋骨草中环二萜类化合物的结构鉴定及其对 NO 生成的抑制作用。
Structure elucidation and inhibitory effects on NO production of clerodane diterpenes from Ajuga decumbens.
机构信息
College of Pharmacy, State Key Laboratory of Medicinal Chemical Biology and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin, China.
出版信息
Planta Med. 2012 Sep;78(14):1579-93. doi: 10.1055/s-0032-1315215. Epub 2012 Aug 7.
Three new clerodane diterpenes (1-3), together with five known analogues (4-8), have been isolated from the whole plants of Ajuga decumbens. Their structures were established by detailed spectroscopic and spectrometric data analyses (IR, ESIMS, HR-ESIMS, 1D and 2D NMR). The inhibitory activities of these diterpenes on LPS-induced NO production were evaluated, and compounds 1-4 and 6-8 showed inhibitory effects.
从直立筋骨草全株中分离得到了 3 个新的 clerodane 二萜（1-3）和 5 个已知类似物（4-8）。通过详细的光谱和光谱数据分析（IR、ESIMS、HR-ESIMS、1D 和 2D NMR）确定了它们的结构。评价了这些二萜类化合物对 LPS 诱导的 NO 产生的抑制活性，结果表明化合物 1-4 和 6-8 具有抑制作用。
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