• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

TGFB1 基因对心肌梗死易感性的贡献。

Contribution of the TGFB1 Gene 
to Myocardial Infarction Susceptibility.

机构信息

Pirogov Russian National Research Medical University , Moscow.

出版信息

Acta Naturae. 2012 Apr;4(2):74-9.

PMID:22872813
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3408705/
Abstract

Carriage frequencies of alleles and genotypes of theTGFB1 gene polymorphous loci -509C>T (rs1800469), 869T>C (rs1982073), 915G>C (rs1800471), which affect the level of cytokine TGF-β1 production, were analyzed in the patients of Russian ethnic descent with myocardial infarction (MI) (406 cases) and in the control group of the same ethnic descent (198 controls). Significant association with MI was observed in carriage frequencies of the alleleTGFB1*-509T (p=0.046, OR =1.45, 95% CI: 1.02-2.06), genotypes TGFB1869T/T (p=0.0024, OR =1.75, 95% CI: 1.22-2.51), andTGFB1915G/G (p=0.048, OR=1.76, 95% CI: 1.05-2.97). Linkage disequilibrium analysis for these SNPs has shown that the associations revealed can be considered to be independent. A complex analysis of MI association with combinations of alleles/genotypes of said SNPs indicates their cumulative effect. An analysis of susceptibility to early-onset MI (≤ 50 years old) revealed a positive association of the alleleTGFB1*-509T (p=0.002, OR=2.24, 95% CI: 1.35-3.71) and genotypeTGFB1869T/T (p=0.008, OR=1.93, 95% CI: 1.18-3.15), as well as their additivity. An analysis of susceptibility to recurrent MI revealed an association of the genotypeTGFB1-509T/T (p=0.0078, OR=2.60, 95% CI: 1.28-5.28). The results obtained indicate the important role of theTGFB1gene in susceptibility to MI, including early-onset and recurrent MI, in Russians.

摘要

对影响细胞因子 TGF-β1 产生水平的 TGFB1 基因多态性位点 -509C>T(rs1800469)、869T>C(rs1982073)、915G>C(rs1800471)的等位基因和基因型在俄罗斯族心肌梗死 (MI) 患者 (406 例) 中的携带频率进行了分析，并与相同民族的对照组 (198 例对照) 进行了比较。结果显示，TGFB1*-509T 等位基因 (p=0.046，OR=1.45，95%CI：1.02-2.06)、TGFB1869T/T 基因型 (p=0.0024，OR=1.75，95%CI：1.22-2.51) 和 TGFB1915G/G 基因型 (p=0.048，OR=1.76，95%CI：1.05-2.97) 的携带频率与 MI 显著相关。对这些 SNP 的连锁不平衡分析表明，所揭示的关联可以被认为是独立的。对所述 SNP 的等位基因/基因型组合与 MI 相关性的综合分析表明，这些 SNP 具有累积效应。对早发性 MI(≤50 岁)易感性的分析显示，TGFB1*-509T 等位基因 (p=0.002，OR=2.24，95%CI：1.35-3.71) 和 TGFB1869T/T 基因型 (p=0.008，OR=1.93，95%CI：1.18-3.15) 具有阳性相关性，且存在累加效应。对复发性 MI 易感性的分析显示，TGFB1-509T/T 基因型 (p=0.0078，OR=2.60，95%CI：1.28-5.28) 与 MI 相关。研究结果表明，TGFB1 基因在俄罗斯人群中易患 MI(包括早发性和复发性 MI)中起重要作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d15f/3408705/d27cc6ce351b/AN20758251-13-074-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d15f/3408705/541c6973744e/AN20758251-13-074-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d15f/3408705/d27cc6ce351b/AN20758251-13-074-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d15f/3408705/541c6973744e/AN20758251-13-074-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d15f/3408705/d27cc6ce351b/AN20758251-13-074-g002.jpg

相似文献

1
Contribution of the TGFB1 Gene 
to Myocardial Infarction Susceptibility.TGFB1 基因对心肌梗死易感性的贡献。
Acta Naturae. 2012 Apr;4(2):74-9.
2
Interaction between smoking and functional polymorphism in the TGFB1 gene is associated with ischaemic heart disease and myocardial infarction in patients with rheumatoid arthritis: a cross-sectional study.吸烟与 TGFB1 基因功能多态性的相互作用与类风湿关节炎患者的缺血性心脏病和心肌梗死有关：一项横断面研究。
Arthritis Res Ther. 2012 Apr 18;14(2):R81. doi: 10.1186/ar3804.
3
Association of TGF-β1 -509C/T, +869T/C, and +915G/C polymorphisms with periodontitis susceptibility.转化生长因子-β1（TGF-β1）-509C/T、+869T/C和+915G/C基因多态性与牙周炎易感性的关联
Oral Dis. 2015 May;21(4):443-50. doi: 10.1111/odi.12297. Epub 2014 Dec 19.
4
TGFB1 mRNA expression and frequency of the + 869T>C and + 915G>C genetic variants: impact on risk for systemic sclerosis.转化生长因子β1（TGFB1）信使核糖核酸（mRNA）表达以及+869T>C和+915G>C基因变异的频率：对系统性硬化症风险的影响
Clin Exp Med. 2023 Aug;23(4):1349-1357. doi: 10.1007/s10238-022-00966-2. Epub 2022 Dec 4.
5
Association between TGF-β1 rs1982073/rs1800469 polymorphism and lung cancer susceptibility: An updated meta-analysis involving 7698 cases and controls.转化生长因子-β1 rs1982073/rs1800469多态性与肺癌易感性的关联：一项纳入7698例病例和对照的最新荟萃分析。
Medicine (Baltimore). 2019 Nov;98(47):e18028. doi: 10.1097/MD.0000000000018028.
6
[Multilocus analysis of the association of polymorphic variants of inflammation genes with ischemic stroke in Russians].[俄罗斯人群中炎症基因多态性变异与缺血性中风关联的多位点分析]
Mol Biol (Mosk). 2016 Jul-Aug;50(4):674-684. doi: 10.7868/S0026898416040145.
7
[Complex analsis of association of inflammation genes with myocardial infarction].[炎症基因与心肌梗死关联的综合分析]
Mol Biol (Mosk). 2010 May-Jun;44(3):463-71.
8
Association of transforming growth factor-beta1 gene polymorphisms with myocardial infarction in patients with angiographically proven coronary heart disease.经血管造影证实的冠心病患者中转化生长因子-β1基因多态性与心肌梗死的关联
Arterioscler Thromb Vasc Biol. 2006 May;26(5):1114-9. doi: 10.1161/01.ATV.0000217747.66517.11. Epub 2006 Mar 16.
9
Association of transforming growth factor-beta 1 gene polymorphism with genetic susceptibility to ossification of the posterior longitudinal ligament in Korean patients.韩国患者中转化生长因子-β1基因多态性与后纵韧带骨化遗传易感性的关联
Genet Mol Res. 2013 Feb 28;12(4):4807-16. doi: 10.4238/2013.February.28.26.
10
Association of transforming growth factor-beta1 gene polymorphisms with genetic susceptibility to nasopharyngeal carcinoma.转化生长因子-β1基因多态性与鼻咽癌遗传易感性的关联
Clin Chim Acta. 2007 May 1;380(1-2):165-9. doi: 10.1016/j.cca.2007.02.008. Epub 2007 Feb 15.

引用本文的文献

1
Analysis of the Association between the Tgfb1 Gene Haplotype and Liver Diseases in Children.儿童Tgfb1基因单倍型与肝脏疾病的关联分析
Acta Naturae. 2023 Jul-Sep;15(3):75-81. doi: 10.32607/actanaturae.19425.
2
Genetic Risk Factors Related to Coronary Artery Disease and Role of Transforming Growth Factor Beta 1 Polymorphisms.与冠状动脉疾病相关的遗传风险因素及转化生长因子β 1 多态性的作用。
Genes (Basel). 2023 Jul 10;14(7):1425. doi: 10.3390/genes14071425.
3
The rs1800470 Polymorphism of the TGFB1 Gene Is Associated with Myocardial Fibrosis in Heart Transplant Recipients.

本文引用的文献

1
Transforming Growth Factor-β1 as a Common Target Molecule for Development of Cardiovascular Diseases, Renal Insufficiency and Metabolic Syndrome.转化生长因子-β1 作为心血管疾病、肾功能不全和代谢综合征共同的靶标分子。
Cardiol Res Pract. 2010 Dec 28;2011:175381. doi: 10.4061/2011/175381.
2
[Complex analsis of association of inflammation genes with myocardial infarction].[炎症基因与心肌梗死关联的综合分析]
Mol Biol (Mosk). 2010 May-Jun;44(3):463-71.
3
Role of TGF-beta1 haplotypes in the occurrence of myocardial infarction in young Italian patients.
转化生长因子β1（TGFB1）基因的rs1800470多态性与心脏移植受者的心肌纤维化相关。
Acta Naturae. 2021 Oct-Dec;13(4):42-46. doi: 10.32607/actanaturae.11469.
4
Association between TGF-β1 -913G/C polymorphism and myocardial infarction risk in a Chinese Han population: a case-control study.TGF-β1-913G/C 多态性与中国汉族人群心肌梗死风险的关联：一项病例对照研究。
Biosci Rep. 2019 Jun 20;39(6). doi: 10.1042/BSR20190315. Print 2019 Jun 28.
5
Variants of the Coagulation and Inflammation Genes Are Replicably Associated with Myocardial Infarction and Epistatically Interact in Russians.凝血与炎症基因的变异与心肌梗死可重复关联且在俄罗斯人群中存在上位性相互作用。
PLoS One. 2015 Dec 10;10(12):e0144190. doi: 10.1371/journal.pone.0144190. eCollection 2015.
转化生长因子β1单倍型在意大利年轻患者心肌梗死发生中的作用
BMC Med Genet. 2008 Feb 29;9:13. doi: 10.1186/1471-2350-9-13.
4
Cytokine gene polymorphism in kidney transplantation--impact of TGF-beta 1, TNF-alpha and IL-6 on graft outcome.肾移植中的细胞因子基因多态性——转化生长因子-β1、肿瘤坏死因子-α和白细胞介素-6对移植肾结局的影响
Transpl Immunol. 2008 Feb;18(4):344-8. doi: 10.1016/j.trim.2007.10.003. Epub 2007 Oct 29.
5
Understanding the role of transforming growth factor-beta1 in intimal thickening after vascular injury.了解转化生长因子-β1在血管损伤后内膜增厚中的作用。
Cardiovasc Res. 2007 May 1;74(2):223-34. doi: 10.1016/j.cardiores.2007.02.012. Epub 2007 Feb 14.
6
TGF-beta 1 polymorphisms and risk of myocardial infarction and stroke: the Rotterdam Study.转化生长因子-β1基因多态性与心肌梗死和中风风险：鹿特丹研究
Stroke. 2006 Nov;37(11):2667-71. doi: 10.1161/01.STR.0000244779.30070.1a. Epub 2006 Oct 5.
7
A molecular mechanism for the differential regulation of TGF-beta1 expression due to the common SNP -509C-T (c. -1347C > T).由于常见单核苷酸多态性-509C-T（c.-1347C>T）导致转化生长因子-β1（TGF-beta1）表达差异调节的分子机制。
Hum Genet. 2006 Nov;120(4):461-9. doi: 10.1007/s00439-006-0194-1. Epub 2006 Aug 1.
8
Association of transforming growth factor-beta1 gene polymorphisms with myocardial infarction in patients with angiographically proven coronary heart disease.经血管造影证实的冠心病患者中转化生长因子-β1基因多态性与心肌梗死的关联
Arterioscler Thromb Vasc Biol. 2006 May;26(5):1114-9. doi: 10.1161/01.ATV.0000217747.66517.11. Epub 2006 Mar 16.
9
Efficiency and power in genetic association studies.基因关联研究中的效率与效能
Nat Genet. 2005 Nov;37(11):1217-23. doi: 10.1038/ng1669. Epub 2005 Oct 23.
10
A Markov chain Monte Carlo technique for identification of combinations of allelic variants underlying complex diseases in humans.一种用于识别人类复杂疾病潜在等位基因变异组合的马尔可夫链蒙特卡罗技术。
Genetics. 2005 Dec;171(4):2113-21. doi: 10.1534/genetics.105.048090. Epub 2005 Aug 22.