Centre for Cancer Biomedicine, Faculty of Medicine, Oslo University Hospital, Montebello, Norway.
BMC Biol. 2012 Aug 8;10:68. doi: 10.1186/1741-7007-10-68.
Eukaryotic cells are distinguished by their compartmentalization into membrane-enclosed organelles that exchange membranes and content in a highly ordered manner. Central in defining membrane identity are the Rabs, a large family of small GTPases that localize to distinct membranes and recruit specific regulators of membrane traffic. Two recent papers, including one by Klöpper et al. in BMC Biology, present phylogenomic evidence that the Rab repertoire was established very early in eukaryotic evolution, and correlates with interspecies variations in organelles.
真核细胞的特点是其膜封闭的细胞器的分隔，这些细胞器以高度有序的方式交换膜和内容物。定义膜特性的核心是 Rab 蛋白，它是一个大型的小 GTPase 家族，定位于不同的膜上，并招募特定的膜运输调节剂。最近的两篇论文，包括 Klöpper 等人在 BMC 生物学上发表的一篇论文，提供了系统发生基因组学证据，表明 Rab 蛋白组在真核生物进化的早期就已经建立，并与细胞器的种间变异相关。
