钴催化的芳基氯与芳基亚胺的邻位芳基化反应。
Cobalt-catalyzed ortho-arylation of aromatic imines with aryl chlorides.
机构信息
Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore.
出版信息
Org Lett. 2012 Aug 17;14(16):4234-7. doi: 10.1021/ol301934y. Epub 2012 Aug 8.
PMID:22873283
Abstract
An ortho-arylation reaction of aromatic imines with aryl chlorides has been achieved using a cobalt-N-heterocyclic carbene catalyst in combination with a neopentyl Grignard reagent. The reaction takes place at room temperature to afford biaryl products in moderate to good yields.
摘要
通过使用钴-氮杂环卡宾催化剂与新戊基格氏试剂的组合，实现了芳基亚胺与芳基氯的正交芳基化反应。该反应在室温下进行，以中等至良好的收率得到联苯产物。
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