National Perinatal Epidemiology Unit, University of Oxford, Oxford, UK.
BJOG. 2014 Feb;121(3):343-55. doi: 10.1111/1471-0528.12437. Epub 2013 Sep 11.
To evaluate the impact of maternal BMI on intrapartum interventions and adverse outcomes that may influence choice of planned birth setting in healthy women without additional risk factors.
Prospective cohort study.
Stratified random sample of English obstetric units.
17,230 women without medical or obstetric risk factors other than obesity.
Multivariable log Poisson regression was used to evaluate the effect of BMI on risk of intrapartum interventions and adverse maternal and perinatal outcomes adjusted for maternal characteristics.
Maternal intervention or adverse outcomes requiring obstetric care (composite of: augmentation, instrumental delivery, intrapartum caesarean section, general anaesthesia, blood transfusion, 3rd/4th degree perineal tear); neonatal unit admission or perinatal death.
In otherwise healthy women, obesity was associated with an increased risk of augmentation, intrapartum caesarean section and some adverse maternal outcomes but when interventions and outcomes requiring obstetric care were considered together, the magnitude of the increased risk was modest (adjusted RR 1.12, 95% CI 1.02-1.23, for BMI > 35 kg/m(2) relative to low risk women of normal weight). Nulliparous low risk women of normal weight had higher absolute risks and were more likely to require obstetric intervention or care than otherwise healthy multiparous women with BMI > 35 kg/m(2) (maternal composite outcome: 53% versus 21%). The perinatal composite outcome exhibited a similar pattern.
Otherwise healthy multiparous obese women may have lower intrapartum risks than previously appreciated. BMI should be considered in conjunction with parity when assessing the potential risks associated with birth in non-obstetric unit settings.
评估母体 BMI 对分娩期干预措施和不良结局的影响,这些因素可能会影响无其他危险因素的健康女性对计划分娩地点的选择。
前瞻性队列研究。
英国产科单位的分层随机抽样。
17230 名除肥胖外无其他医学或产科危险因素的女性。
使用多变量对数泊松回归评估 BMI 对分娩期干预措施和不良母婴围产结局的影响,这些结局经母体特征调整。
需要产科护理的母体干预或不良结局(包括催产、器械分娩、分娩期剖宫产、全身麻醉、输血、三度/四度会阴撕裂);新生儿入住新生儿病房或围产儿死亡。
在其他方面健康的女性中,肥胖与催产、分娩期剖宫产和一些不良母婴结局的风险增加有关,但当考虑到需要产科护理的干预措施和结局时,风险增加的幅度不大(调整后的 RR 为 1.12,95%CI 1.02-1.23,BMI > 35 kg/m2 与低风险正常体重女性相比)。低危初产妇正常体重的绝对风险较高,比其他方面健康的 BMI > 35 kg/m2 的经产妇更有可能需要产科干预或护理(母体复合结局:53%比 21%)。围产儿复合结局表现出类似的模式。
其他方面健康的多产妇肥胖女性可能比之前认为的分娩期风险低。在评估非产科单位分娩相关潜在风险时,应将 BMI 与产次结合考虑。