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The ethics of early evidence--preparing for a possible breakthrough in Alzheimer's disease.

作者信息

Lowenthal Justin, Hull Sara Chandros, Pearson Steven D

机构信息

Department of Bioethics, Clinical Center, National Institutes of Health, Bethesda, MD, USA.

出版信息

N Engl J Med. 2012 Aug 9;367(6):488-90. doi: 10.1056/NEJMp1203104.

DOI:10.1056/NEJMp1203104
PMID:22873528
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3469579/
Abstract
摘要

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本文引用的文献

1
ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models.载脂蛋白 E 靶向治疗能迅速清除β-淀粉样蛋白并逆转 AD 小鼠模型的缺陷。
Science. 2012 Mar 23;335(6075):1503-6. doi: 10.1126/science.1217697. Epub 2012 Feb 9.
2
Patient-reported outcomes as a source of evidence in off-label prescribing: analysis of data from PatientsLikeMe.患者报告结局作为超说明书用药证据的来源：对PatientsLikeMe数据的分析
J Med Internet Res. 2011 Jan 21;13(1):e6. doi: 10.2196/jmir.1643.
3
Off-label prescribing: a call for heightened professional and government oversight.超说明书用药：呼吁加强专业人员及政府监管。
J Law Med Ethics. 2009 Fall;37(3):476-86, 396. doi: 10.1111/j.1748-720X.2009.00408.x.